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Note: This manual is a very large document. You may find it somewhat slow to load.
See: World Health Organizations's LABORATORY BIOSAFETY MANUAL 
Guidelines for Recombinant DNA Research
Experiments Covered by the NIH Guidelines
Specific guidance on which experiments have to be reported to the NIH Office of Biotechnology Activity, the MSSM Institutional Biosafety Committee in accordance with NIH requirements. -
Exemptions and Host-Vector Systems Guide
Certain specified recombinant DNA molecules that consist entirely of DNA segments from different species that exchange DNA by known physiological processes, though one or more of the segments may be a synthetic equivalent, are exempt from the NIH Guidelines.
Exempt Experiments - Definition
Certain recombinant DNA molecules are exempt from the NIH Guidelines, and registration with the Institutional Biosafety Committee is not required by the NIH. Rules for Filing Recombinant DNA Activities Entrez Gene: Gene-centered Information at NCBI
Entrez Gene is NCBI's database for gene-specific information. It does not include all known or predicted genes; instead Entrez Gene focuses on the genomes that have been completely sequenced, that have an active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. The content of Entrez Gene represents the result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. The content (nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains, and external databases) is updated as new information becomes available. Entrez Gene is a step forward from NCBI's LocusLink, with both a major increase in taxonomic scope and improved access through the many tools associated with NCBI Entrez.
This information offered here should be used in filling out the "Nature of Inserted Sequences" sections on the MSSM IACUC Form 3, Part C, found at www.mssm.edu/iacuc/forms.shtml,
and the IBC Certificate of Registration found at www.mssm.edu/biosafety/forms.shtml.
Entrez Gene Web site: www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene
CDC/USDA Select Agents Registration
Before you order any of these materials, you will need to consult with the Biosafety Officer about the correct procedures for possession/use. You may have to file documents with the CDC, USDA or both agencies simultaneously to possess and work with these agents. You may have to submit to a background check by the FBI and submit fingerprints to the Department of Justice under "The Patriot Act", since these materials are highly restricted and regulated by these agencies.
If the agent is present on the list and is not covered by an exclusion, you must file a registration document with the appropriate agency.
MSSM Select Agent Program Documents
See: World Health Organization's
Guidelines for the Safe Transport of Infectious Substances and Diagnostic Specimens
This Web site provides imformation on how to obtain permits that allow you to either import or export infectious agents or biological materials requiring these permits.
Failure to obtain the correct permits can result in delay, loss of, and (or), damage to specimens due to impoundment at United States Customs Facilities. If the agent is a Select Agent as defined by the CDC, you must file paper work and obtain permission from the CDC to possess and work with the select agent before applying for an import / export permit.
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