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Dara Dickstein
I received my PhD in Medical Genetics from the University of British Columbia in 2004. Since then I have been at Mount Sinai, originally as a Postdoctoral Fellow in the Department of Neuroscience and now as an Instructor. My research interests include the pathological aspects of aging and neuro-degenerative diseases such as Alzheimer's disease. My thesis work addressed the molecular aspects of Alzheimer's disease, in particular the role of amyloid beta and inflammation in the disease process as well as on blood-brain barrier integrity. My current research centers on the anatomical changes that occur in neurons during aging and neurodegeneration. Studies focus on the use of various mouse models of Alzheimer's disease with mutations in the amyloid precursor protein, presenilin and Tau, and employ techniques such as cell loading, three-dimensional cell reconstruction, immunohistochemistry, stereology, and fluorescent and confocal microscopy. |