Research Resources
Systems Biology Center New York
The Systems Biology Center New York (SBCNY) is one of the National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS). Researchers and educators from Mount Sinai School of Medicine, Courant Institute of Mathematical Sciences NYU, Stony Brook University (SUNY), City University of New York (CUNY), National Centre for Biological Sciences (India), and the IBM T.J. Watson Research Center, form the Systems Biology Center New York. SBCNY investigators want to understand how the effects of molecular interactions are propagated across scales of organization from cells to tissues and organs affecting physiology and pathophysiology. We posit that the dynamic organization of motifs (regulatory loops) within multi-scale networks provides the basis for propagation of effects across scales from molecules to cells to tissues. We study drug action at a genomic scale to understand and predict adverse events. We are actively engaged in the development of the new discipline of Systems Pharmacology.
Software, databases and data generated by the Systems Biology Center New York are publicly available, and research findings are described in the Center's publications.
Experimental Therapeutics Institute
The Experimental Therapeutics Institute (ETI) serves as the interdisciplinary institutional platform for the development of new drugs, devices, and intellectual property that grow out of Mount Sinai’s basic and clinical research programs. This Institute provides a range of emerging and established technologies to Mount Sinai researchers that enable the translation of basic biological mechanisms into therapeutics. The services provided by the Institute include high-throughput screening of chemical libraries, medicinal chemistry, pharmacokinetics and pharmacodynamics and computation and systems pharmacology.
The ETI Cores include:
- Integrated Screening Core
- Medicinal Chemistry Core
- Molecular Informatics Core
- Systems Pharmacology-Bioinformatics and Computational Core
- Pharmacokinetics and Pharmacodynamics Core
MSSM Research Administration
- Environmental Health and Safety Offices
- Office of Technology and Business Development
- Center for Comparative Medicine and Surgery
- Program for the Protection of Human Subjects
- Institutional Animal Care and Use Committee
- Office of Clinical Research
- Conflicts of Interest in Research
Grant Support
- Grants and Contracts Office
- InfoEd Electronic Research Administration
- InfoEd Training Module
- Sinai Central
- Sinai Knowledge - Support site for Sinai Central
- National Institutes of Health
- NIH eRA Commons
- NIH RePorter
Education and Training Resources
Graduate Course Materials
- Applied Mathematics for Biologists
- Cell Signaling Systems
- Pharmacogenomics
- Systems Biology--Biomedical Modeling
- Systems Biomedicine: Molecules, Cells and Networks
Teaching Resources and Education Publications
Teaching Resources
Systems biology--biomedical modeling. Sci Signal. 2011 Sep 13;4(190):tr2. PMID: 21917716
Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment. Sci Signal. 2008;1(9):tr2. PMID: 18323015
Teaching resources. Cell signaling systems: a course for graduate students. Sci STKE. 2005 Feb 1;2005(269):tr3. PMID: 15687508
Graduate Education and Training Publications
Training in systems pharmacology: predoctoral program in pharmacology and systems biology at Mount Sinai School of Medicine. Clin Pharmacol Ther. 2010 Jul;88(1):19-22. PMID: 20562890
Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29;319(5867):1189-90. PMID: 18309063
