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Handbook for Research
Section II: Guidelines for the Conduct of Research
Issues in Data Analysis and Interpretation
Self-delusion is an ever-present danger to the creative
scientist intent on making important discoveries and laboring
under pressures for timely publication of the results. It
is self-delusion, rather than the intent to deceive others,
that underlies many reports of invalid conclusions. Strong
belief in a particular hypothesis, for example, may lead to
the ready acceptance of confirmatory results with disregard
of the possibility that additional experiments may reveal
unexpected discrepancies or throw doubt on the reliability
of a new technique used.
Investigators are encouraged to develop experimental designs
that will minimize the opportunity for self-deception, e.g.,
use of blinded samples, adequate number of samples and repetitions,
and rigorously defined and evaluated controls. They are also
reminded that the irksome trainee who challenges the laboratory's
hypothesis may often be the most valuable member of the team,
and that frequent oral presentations of data to the group
and colleagues favor the timely identification of flaws.
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