General Information

In the search for reality, all roads lead to scientific discovery.

Welcome to the General Clinical Research Center (GCRC) at Mount Sinai School of Medicine, located on the second floor of 1184 Fifth Avenue. This resource, founded in 1965, is designed to facilitate clinical research by Mount Sinai faculty members and staff and is supported by a grant from the National Center for Research Resources of the National Institutes of Health. The GCRC provides the necessary infrastructure and training for Mount Sinai investigators to conduct their research studies, and resources are utilized by investigators who wish assistance in all aspects of research design, methodology and the actual carrying out of the study as the GCRC is staffed by nurses with advanced degrees (i.e. nurse practitioners).

Currently, there are over one hundred studies that are conducted at the GCRC in the following disciplines:

• Endocrinology: Role of insulin in modulating responsiveness to androgens in ovarian dysfunction; evaluation of ethnic factors influencing bone mass in female population.
• Genetic Diseases: Molecular basis of phenotypic variation in Fabry's and Gaucher's diseases; therapy of inborn errors of metabolism (including enzyme deficiencies, amino acid disorders, lipid storage diseases) by dietary, cofactor, transplantation, enzyme replacement, and recombinant DNA approaches; natural history of inborn errors of metabolism and other genetic diseases (such as Niemann-Pick Disease).
• Geriatrics: Drug metabolism; endogenous formation of advanced glycation end products (AGEs) in diabetes.
• Hematology: Growth and development in children with hemophilia; beta-globin disorders.
• Internal medicine: Vasodialator response in heart failure; effect of lowering cholesterol in thrombotic factors; lead mobilization during pregnancy and lactation in young urban women.
• Neurology: Therapy of parkinsonism, myoclonus, dysautonomia, and seizure disorders; HIV dementia; peptide-T in HIV-positive patients.
• Pediatrics: Immunopathogenetic mechanisms of food hypersensitivity in children with atopic dermatitis; cow-milk induced hypersensitivities; peanut hypersensitivity.
• Psychiatry: Role of glucose metabolism, cholinergic neurotransmitters in memory function in Alzheimer's disease; biochemical alterations in schizophrenia and schizophrenia spectrum disorders; post-traumatic stress disorder; major depression, autism and autistic spectrum disorders; obsessive-compulsive, dissociative and impulse control disorders.

If you’re unsure whether the GCRC can be of assistance to your research efforts, please call (212) 241-6045.

Before the implementation of any protocol in the GCRC facility, the study must be reviewed by the GCRC scientific advisory committee in addition to being approved by the Mount Sinai IRB. The committee, which meets monthly and is chaired by M. Klotman, M.D., is comprised of a team of nineteen investigators whose expertise spans all areas of clinical research.

For applications, and forms please look under Investigator Information.

Contact Information

Administrator
Tel: (212) 241-6045