2008 Publications

C.I. YU, M. GALLEGOS, F. MARCHES, G. ZURAWSKI, O. RAMILO, A. GARCÍA-SASTRE, J. BANCHEREAU & A.K. PALUCKA: Influenza virus vaccines induce broad influenza-specific CD8+ T cell responses in humanized mice. Blood, (in press).

L.A. PERRONE, J.K. PLOWDEN, A. GARCÍA-SASTRE, J.M. KATZ & T.M. TUMPEY: H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathogens, (in press).

C. MUÑOZ-FONTELA, S. MACIP, L. MARTÍNEZ-SOBRIDO, L. BROWN, J. ASHOUR, A. GARCÍA-SASTRE, S.W. LEE & S.A. AARONSON: Transcriptional role of p53 in Interferon-mediated antiviral immunity. Journal of Experimental Medicine, (in press).

L. WU, T.G. HUANG, M. MESECK, J. ALTOMONTE, O. EBERT, K. SHINOZAKI, A. GARCÍA-SASTRE, J. FALLON, J. MANDELI & S.L. WOO: rVSV(MDelta51)-M3 Is an Effective and Safe Oncolytic Virus for Cancer Therapy. Human Gene Therapy, 19, 635-647 (2008).

L. WANG, D.L. SUAREZ, M. PANTIN-JACKWOOD, M. MIBAYASHI, A. GARCÍA-SASTRE, Y.M. SAIF & C.W. LEE: Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as a live influenza vaccine in poultry.
Vaccine, 26, 3580-3586 (2008).

S. WANG, C. PARKER, J. TAAFFE, A. SOLÓRZANO, A. GARCÍA-SASTRE & S. LU: Heterologous HA DNA vaccine prime-inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses. Vaccine, 26, 3626-3633 (2008).

C. PAPPAS, P.V. AGUILAR, C.F. BASLER, A. SOLÓRZANO, H. ZENG, L.A. PERRONE, P. PALESE, A. GARCÍA-SASTRE, J.M. KATZ & T.M. TUMPEY: Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus. Proceedings of the National Academy of Sciences, USA, 105, 3064-3069 (2008).

J. DITTMANN, S. STERTZ, D. GRIMM, J. STEEL, A. GARCÍA-SASTRE, O. HALLER & G. KOCHS: Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. Journal of Virology, 82, 3624-3631 (2008).

C.-H. SHEN, Q. GE, O. TALAY, H.N. EISEN, A. GARCÍA-SASTRE & J. CHEN: Loss of IL-7R and IL-15R expression is associated with disappearance of memory T cells in respiratory tract following influenza infection. Journal of Immunology, 180, 171-178 (2008).

I.A. COCKBURN, S. CHAKRAVARTY, M.G. OVERSTREET, A. GARCÍA-SASTRE & F. ZAVALA: Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation. Journal of Immunology, 180, 64-71 (2008).

J. STEEL, S.V. BURMAKINA, C. THOMAS, E. SPACKMAN, A. GARCÍA-SASTRE, D.E. SWAYNE & P. PALESE: A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus. Vaccine, 26, 522-531 (2008).

B. SQUIRES, C. MACKEN, A. GARCÍA-SASTRE, S. GODBOLE, J. NORONHA, V. HUNT, R. CHANG, C.N. LARSEN, E. KLEM, K. BIERSACK, & R.H. SCHEUERMANN: BioHealthBase: informatics support in the elucidation of influenza virus host pathogen interactions and virulence. Nucleic Acids Research, 36(Database issue), D497-503 (2008).

J. ALTOMONTE, L. WU, L. CHEN, M. MESECK, O. EBERT, A. GARCÍA-SASTRE, J. FALLON & S.L. WOO: Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo. Molecular Therapy, 16, 146-153 (2008).

Y.M. LOO, J. FORNEK, N. CROCHET, G. BAJWA, O. PERWITASARI, L. MARTINEZ-SOBRIDO, S. AKIRA, M.A. GILL, A. GARCÍA-SASTRE, M.G. KATZE & M. GALE Jr.: Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. Journal of Virology, 82, 335-345 (2008).

2007 Publications

N. FRIAS-STAHELI, N.V. GIANNAKOPOULOS, M. KIKKERT, S.L. TAYLOR, A. BRIDGEN, J.J. PARAGAS, J.A. RICHT, R.R. ROWLAND, C.S. SCHMALJOHN, D.J. LENSCHOW, E.J. SNIJDER, A. GARCÍA-SASTRE* & H.W. VIRGIN IV*: Ovarian tumor (OTU)-domain containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell, Host and Microbe, 2, 404-416 (2007).
*Corresponding authors.

A.L. VINCENT, W. MA, K.M. LAGER, B.H. JANKE, R.J. WEBBY, A. GARCÍA-SASTRE & J.A. RICHT: Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine, 25, 7999-8009 (2007).

L. MARTÍNEZ-SOBRIDO, P. GIANNAKAS, B. CUBITT, A. GARCÍA-SASTRE & J.C. DE LA TORRE: Differential inhibition of type I interferon induction by arenavirus nucleoproteins. Journal of Virology, 81, 12696-12703 (2007).

C.R. BASKIN, H. BIELEFELDT-OHMANN, A. GARCÍA-SASTRE, T.M. TUMPEY, N. VAN HOEVEN, V.S. CARTER, M.J. THOMAS, S. PROLL, A. SOLÓRZANO, R. BILLHARZ, J.L. FORNEK, S. THOMAS, C-H. CHEN, E.A. CLARK, K. MURALI-KRISHNA & M.G. KATZE: Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. Journal of Virology, 81, 11817-11827 (2007).

N. TSUDA, D.Z. CHANG, T. MINE, C. EFFERSON, A. GARCÍA-SASTRE, X. WANG, S. FERRONE & C.G. IOANNIDES: Taxol increases the amount and T cell-activating ability of self-stimulatory multimolecular complexes found in ovarian cancer cells. Cancer Research, 67, 8378-8387 (2007).

A. VIGIL, M.-S. PARK, O. MARTINEZ, M.A. CHUA, S. XIAO, J.F. CROS, L. MARTÍNEZ-SOBRIDO, S.L.C. WOO & A. GARCÍA-SASTRE: Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus. Cancer Research, 67, 8285-8292 (2007).

T.M. TUMPEY, K.J. SZRETTER, N. VAN HOEVEN, J.M. KATZ, G. KOCHS, O. HALLER, A. GARCÍA-SASTRE & P. STAEHELI: The Mx1 gene protects mice against pandemic 1918 and highly lethal human H5N1 influenza viruses. Journal of Virology, 81, 10818-10821 (2007).

I. LEGASTELOIS, A. GARCÍA-SASTRE, P. PALESE, T.M. TUMPEY, T.R. MAINES, J.M. KATZ, F.R. VOGEL & C. MOSTE: Preparation of genetically engineered A/H5N1 and A/H7N1 pandemic vaccine viruses by reverse genetics in a mixture of Vero and chicken embryo cells. Influenza and Other Respiratory Viruses, 1, 95-104 (2007).

T. IRIE, E. CARNERO, A. OKUMURA, A. GARCÍA-SASTRE & R.N. HARTY: Modifications of the PSAP region of the matrix protein lead to attenuation of VSV in vitro and in vivo. Journal of General Virology, 88, 2558-2567 (2007).

M. SALVATORE, A. GARCÍA-SASTRE, P. RUCHALA, R.I. LEHRER, T. CHANG & M.E. KLOTMAN: Alpha-defensin inhibits influenza virus replication by cell mediated mechanism(s). Journal of Infectious Diseases, 196, 835-843 (2007).

Q. HE, L. MARTINEZ-SOBRIDO, F.O. EKO, P. PALESE, A. GARCÍA-SASTRE, D. LYN, D. OKENU, C. BANDEA, G.A. ANANABA, C.M. BLACK & J.U. IGIETSEME: Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines. Immunology, 122, 28-37 (2007).

P.L. QUAN, G. PALACIOS, O.J. JABADO, S. CONLAN, D.L. HIRSCHBERG, F. POZO, P.J. JACK, D. CISTERNA, N. RENWICK, J. HUI, A. DRYSDALE, R. AMOS-RITCHIE, E. BAUMEISTER, V. SAVY, K.M. LAGER, J.A. RICHT, D.B. BOYLE, A. GARCÍA-SASTRE, I. CASAS, P. PEREZ-BREÑA, T. BRIESE & W.I. LIPKIN: Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray. Journal of Clinical Microbiology, 45, 2395-2364 (2007).

L. MARTÍNEZ-SOBRIDO & A. GARCÍA-SASTRE: Recombinant influenza virus vectors. Future Virology, 2, 401-416 (2007).

A. GHANEM, D. MAYER, G. CHASE, W. TEGGE, R. FRANK, G. KOCHS, A. GARCÍA-SASTRE & M. SCHWEMMLE: Peptide-mediated interference with influenza A virus polymerase. Journal of Virology, 81, 7801-7804 (2007).

C.R. ESCALANTE, E. NISTAL-VILLÁN, L. SHEN, A. GARCÍA-SASTRE & A.K. AGGARWAL: Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Molecular Cell, 8, 703-716 (2007).

J.K. ROTH-CROSS, L. MARTÍNEZ-SOBRIDO, E.P. SCOTT, A. GARCÍA-SASTRE & S.R. WEISS: Inhibition of the alpha /beta interferon response by mouse hepatitis virus at multiple levels. Journal of Virology, 81, 7189-7199 (2007).

G. KOCHS, A. GARCÍA-SASTRE & L. MARTÍNEZ-SOBRIDO: Multiple anti-interferon actions of the influenza A virus NS1 protein. Journal of Virology, 81, 7011-7021 (2007).

X. WANG, S. HUSSEIN, E-J. WANG, X. WANG, M.O. LI, A. GARCÍA-SASTRE & A.A. BEG: Lack of essential role of NF-kappaB p50, RelA and cRel subunits in virus-induced type 1 interferon expression. Journal of Immunology, 178, 6770-6776 (2007).

A. GARCÍA-SASTRE: A macaque model of influenza virus infection reveals severe respiratory disease associated with infection of the 1918 pandemic strain. Cellscience Reviews, 3(4), 1-8 (2007).

S. STERTZ, M. REICHELT, M. SPIEGEL, T. KURI, L. MARTÍNEZ-SOBRIDO, A. GARCÍA-SASTRE, F. WEBER & G. KOCHS: The intracellular sites of early replication and budding of SARS-coronavirus. Virology, 361, 305-315 (2007).

D. GRIMM, P. STAEHELI, M. HUFBAUER, I. KOERNER, L. MARTÍNEZ- SOBRIDO, A. SOLÓRZANO, A. GARCÍA-SASTRE, O. HALLER & G. KOCHS: Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proceedings of the National Academy of Sciences, USA, 104, 6806-6811 (2007).

F. PUIG-BASAGOITI, M. TILGNER, C.J. BENNETT, Y. ZHOU. J.L. MUÑOZ-JORDÁN, A. GARCÍA-SASTRE, K.A. BERNARD & P.-Y. SHI: A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis. Virology, 361, 229-241 (2007).

B.R. TENOEVER, S.-L. NG, M.A. CHUA, S.M. MCWHIRTER, A. GARCÍA-SASTRE & T. MANIATIS: Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science, 315, 1274-1278 (2007).

T.M. TUMPEY, T.R. MAINES, N. VAN HOEVEN, L. GLASER, A. SOLÓRZANO, C. PAPPAS, N.J. COX, D.E. SWAYNE, P. PALESE, J.M. KATZ & A. GARCÍA-SASTRE: A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science, 315, 655-659 (2007).

D. MAYER, K. MOLAWI1, L. MARTÍNEZ-SOBRIDO, A. GHANEM, S. THOMAS, S. BAGINSKY, J. GROSSMANN, A. GARCÍA-SASTRE & M. SCHWEMMLE: Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches. Journal of Proteome Research, 6, 672-682 (2007).

D.J. LENSCHOW, C. LAI, N. FRIAS-STAHELI, N.V. GIANNAKOPOULOS, A. LUTZ, T. WOLFF, A. OSIAK, B. LEVINE, R.E. SCHMIDT, A. GARCÍA-SASTRE, D.A. LEIB, A. PEKOSZ, K.-P. KNOBELOCH, I. HORAK & H.W. VIRGIN IV: IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes and Sindbis viruses. Proceedings of the National Academy of Sciences, USA, 104, 1371-1376 (2007).

C.F. BASLER & A. GARCÍA-SASTRE: Sensing RNA virus infections. Nature Chemical Biology, 3, 20-21 (2007).

M. MIBAYASHI, L. MARTINEZ-SOBRIDO, Y.M. LOO, W.B. CARDENAS, M. GALE JR. & A. GARCÍA-SASTRE: Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. Journal of Virology, 81, 514-524 (2007).

2006 Publications

S. WANG, J. TAAFFE, C. PARKER, A. SOLORZANO, H. CAO, A. GARCÍA-SASTRE & S. LU: Hemagglutinin (HA) proteins from H1 and H3 serotypes of influenza A viruses require different antigen designs for the induction of optimal protective antibody responses as studied by codon optimized HA DNA vaccines. Journal of Virology, 80, 11628-11637 (2006).

W.P. KONG, C. HOOD, Z.Y. YANG, C.J. WEI, L. XU, A. GARCÍA-SASTRE, T.M. TUMPEY & G.J. NABEL: Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination. Proceedings of the National Academy of Sciences, USA, 103, 15987-15991 (2006).

J.A. RICHT, P. LEKCHAROENSUK, K.M. LAGER, A.L. VINCENT, C.M. LOIACONO, B.H. JANKE, W.-H. WU, K.-J. YOON, R.J. WEBBY, A. SOLÓRZANO & A. GARCÍA-SASTRE: Vaccination of pigs against swine influenza viruses using an NS1-truncated modified live virus vaccine. Journal of Virology, 80, 11009-11018 (2006).

T. BAAS, C.R. BASKIN, D.L. DIAMOND, A. GARCÍA-SASTRE, H. BIELEFELDT-OHMANN, T.M. TUMPEY, M.J. THOMAS, V.S. CARTER, T.H. TEAL, N. VAN HOEVEN, S. PROLL, J.M. JACOBS, Z.R. CALDWELL, M.A. GRITSENKO, R.R. HUKKANEN, D.G. CAMP II, R.D. SMITH & M.G. KATZE: Integrated molecular signature of disease: Analysis of influenza virus-infected macaques through functional genomics and proteomics. Journal of Virology, 80, 10813-10828 (2006).

J.C. KASH, T.M. TUMPEY, S.C. PROLL, V. CARTER, O. PERWITASARI, M.J. THOMAS, C.F. BASLER, P. PALESE, J.K. TAUBENBERGER, A. GARCÍA-SASTRE, D.E. SWAYNE & M.G. KATZE: Genomic analysis of increased host immune and cell death responses by 1918 influenza virus. Nature, 443, 578-581 (2006).

A. GARCÍA-SASTRE & R. WHITLEY: Lessons learned from reconstructing the 1918 influenza virus pandemic. Journal of Infectious Diseases, 94, S127-S132 (2006).

L. MARTÍNEZ-SOBRIDO, E.I. ZÚÑIGA, D. ROSARIO, A. GARCÍA-SASTRE & J.C. DE LA TORRE: Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. Journal of Virology, 80, 9192-9199 (2006).

L. MARTÍNEZ-SOBRIDO & A. GARCÍA-SASTRE: Virus complementation assays to identify interferon antagonists. In “Viral Immunity. Methods and Protocols”, R. Donis & J.M. Katz (Eds.), Humana Press Inc. (2006).

A.C. LOWEN, S. MUBAREKA, T.M. TUMPEY, A. GARCÍA-SASTRE & P. PALESE: The guinea pig as a transmission model for human influenza viruses. Proceedings of the National Academy of Sciences, USA, 103, 9988-9992 (2006).

A. FERNANDEZ-SESMA, S. MARUKIAN, B.J. EBERSOLE, D.KAMINSKI, M.-S. PARK, T. YUEN, S.C. SEALFON, A. GARCÍA-SASTRE & T.M. MORAN: Influenza virus evades innate and adaptive immunity via the NS1 protein. Journal of Virology, 80, 6295-6304 (2006).

M-S. PARK, J. STEEL, A. GARCÍA-SASTRE, D. SWAYNE & P. PALESE: Engineered viral vaccine constructs with dual specificity: Avian influenza and Newcastle disease. Proceedings of the National Academy of Sciences, USA, 103, 8203-8208 (2006).

A. GARCÍA-SASTRE & C.A. BIRON: Type 1 interferon and the virus-host relationship: A lesson in détente. Science, 312, 879-882 (2006).

L. GLASER, D. ZAMARIN, H.M. ACLAND, E. SPACKMAN, P. PALESE, A. GARCÍA-SASTRE & D. TEWARI: Sequence analysis and receptor specificity of the hemagglutinin of a recent influenza H2N2 virus isolated from chicken in North America. Glycoconjugate Journal, 23, 93-99 (2006).

A. GARCÍA-SASTRE: Antiviral response in pandemic influenza viruses. Emerging Infectious Diseases, 12, 44-47 (2006).

P. PALESE, T.M. TUMPEY & A. GARCÍA-SASTRE: What can we learn from reconstructing the extinct 1918 pandemic influenza virus? Immunity, 24, 121-124 (2006).

L. MARTINEZ-SOBRIDO, N. GITIBAN, A. FERNANDEZ-SESMA, J. CROS, S.E. MERTZ, N.A. JEWELL, S. HAMMOND, E. FLANO, R.K. DURBIN, A. GARCÍA-SASTRE, & J.E. DURBIN: Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector. Journal of Virology, 80, 1130-1139 (2006).

S.M. CARR, E. CARNERO, A. GARCÍA-SASTRE, G.G. BROWNLEE & E. FODOR: Characterization of a mitochondrial targeting signal in the PB2 protein of influenza viruses. Virology, 344, 492-508 (2006).

C.L. EFFERSON, N. TSUDA, K. KAWANO, E. NISTAL-VILLÁN, S. SELLAPPAN, D. YU, J.L. MURRAY, A. GARCÍA-SASTRE & C.G. IOANNIDES: Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells. Journal of Virology, 80, 383-394 (2006).

2005 Publications

J.U. IGIETSEME, Q. HE, F. O. EKO, L. MARTINEZ-SOBRIDO, P. PALESE, A. GARCÍA-SASTRE & C. BLACK: Development of vaccines to prevent chlamydial STDs. Mucosal Immunology Update, 13 (4), 11-17 (2005).

J. IGIETSEME, F. EKO, Q. HE, C. BANDEA, W. LUBITZ, A. GARCÍA-SASTRE & C. BLACK: Delivery of Chlamydia vaccines. Expert Opinion on Drug Delivery, 2, 549-562 (2005).

T.M. TUMPEY, A. GARCÍA-SASTRE, J.K. TAUBENBERGER, P. PALESE, D.E. SWAYNE, M.J. PANTIN-JACKWOOD, S. SCHULTZ-CHERRY, A. SOLORZANO, N. VAN ROOIJEN, J.M. KATZ & C.F. BASLER: Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. Journal of Virology, 79, 14933-14944 (2005).

T.M. TUMPEY, C.F. BASLER, P.V. AGUILAR, H. ZENG, A. SOLORZANO, D.E. SWAYNE, N.J. COX, J.M. KATZ, J.K. TAUBENBERGER, P. PALESE & A. GARCÍA-SASTRE: Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science, 310, 77-80 (2005).
This paper was selected “paper of the year 2005” by Lancet (Lancet, 367, 636, 2006)

D. ZAMARIN, A. GARCÍA-SASTRE, X. XIAO, R. WANG & P. PALESE: Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathogens, 1, 40-54 (2005).

A.M. FALCÓN, A. FERNANDEZ-SESMA, Y. NAKAYA, T.M. MORAN, J. ORTÍN & A. GARCÍA-SASTRE: Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins. Journal of General Virology, 86, 2817-2821 (2005).

L. GLASER, J. STEVENS, D. ZAMARIN, I.A. WILSON, A. GARCÍA-SASTRE, T.M. TUMPEY, C.F. BASLER, J.K. TAUBENBERGER & P. PALESE: A single amino acid substitution in the 1918 influenza virus hemagglutinin changes the receptor binding specificity. Journal of Virology, 79, 11533-11536 (2005).

M. QUINLIVAN, D. ZAMARIN, A. GARCÍA-SASTRE, A. CULLINANE, T. CHAMBERS & P. PALESE: Attenuation of equine influenza viruses through truncations of the NS1 protein. Journal of Virology, 79, 8431-8439 (2005).

J.L. MUÑOZ-JORDÁN, M. LAURENT-ROLLE, J. ASHOUR, L MARTÍNEZ-SOBRIDO, M. ASHOK, W.I. LIPKIN & A. GARCÍA-SASTRE: Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. Journal of Virology, 79, 8004-8013 (2005).

S.V. BOURMAKINA & A. GARCÍA-SASTRE: The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells. Journal of Virology, 79, 7926-7932 (2005).

A. SOLÓRZANO, R.J. WEBBY, K.M. LAGER, B.H. JANKE, A. GARCÍA-SASTRE & J.A. RICHT: Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. Journal of Virology, 79, 7535-7543 (2005).

C.L. EFFERSON, K. KAWANO, N. TSUDA, P. PALESE, A. GARCÍA-SASTRE & C.G. IOANNIDES: Stimulation of human T cells by an influenza A vector expressing a CTL epitope from the HER-2/neu protooncogene results in higher numbers of antigen-specific TCRhi cells than stimulation with peptide. Divergent roles of IL-2 and IL-15. Anticancer Research, 25, 715-724 (2005).

A. BERTOLOTTI-CIARLET, J. SMITH, K. STRECKER, J. PARAGAS, L.A. ALTAMURA, J.M. McFALLS, N. FRIAS-STÄHELI, A. GARCÍA-SASTRE, C.S. SCHMALJOHN & R.W. DOMS: Cellular localization and antigenic characterization of Crimean-Congo hemorrhagic fever virus glycoproteins. Journal of Virology, 79, 6152-6161 (2005).

J.F. CROS, A. GARCÍA-SASTRE & P. PALESE: An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein. Traffic, 6, 205-213 (2005).

C.F. BASLER, A. GARCÍA-SASTRE & P. PALESE: A novel paramyxovirus? Emerging Infectious Diseases, 11, 108-112 (2005).

M. SPIEGEL, A. PICHLMAIR, L. MARTÍNEZ-SOBRIDO, J. CROS, A. GARCÍA-SASTRE, O. HALLER & F. WEBER: Inhibition of beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. Journal of Virology, 79, 2079-2086 (2005).

F. MARCOS, L. FERREIRA, J. CROS, M.-S. PARK, T. NAKAYA, A. GARCÍA-SASTRE & E. VILLAR: Mapping of the RNA promoter of Newcastle disease virus. Virology, 331, 396-406 (2005).

S. JENNINGS, L. MARTINEZ-SOBRIDO, A. GARCÍA-SASTRE, F. WEBER & G. KOCHS: Thogoto virus ML protein suppresses IRF3 function. Virology, 331, 63-72 (2005).

Selected Publications from Previous Years

N.R. DONELAN, B. DAUBER, X. WANG, C.F. BASLER, T. WOLFF & A. GARCÍA-SASTRE: The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation. Journal of Virology, 78, 11574 11582 (2004).

Y. NAKAYA, T. NAKAYA, M.-S. PARK, J. CROS, J. IMANISHI, P. PALESE & A. GARCÍA-SASTRE: Induction of cellular immune responses to SIV gag by two recombinant negative-strand RNA virus vectors. Journal of Virology, 78, 9366 9375 (2004).

T.M. TUMPEY, A. GARCÍA-SASTRE, J.K. TAUBENBERGER, P. PALESE, D.E. SWAYNE & C.F. BASLER: Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. Proceedings of the National Academy of Sciences (U.S.A.), 101, 3166 3171 (2004).

N. DONELAN, C.F. BASLER & A. GARCÍA-SASTRE: A recombinant influenza A virus expressing an RNA-binding defective NS1 protein induces high levels of IFN-ß and is attenuated in mice. Journal of Virology, 77, 13257-13266 (2003).

J. MUÑOZ-JORDÁN, G.G. SÁNCHEZ-BURGOS, M. LAURENT-ROLLE & A. GARCÍA-SASTRE: Inhibition of interferon signaling by dengue virus. Proceedings of the National Academy of Sciences (U.S.A.), 100, 14333-14338 (2003).

G. GONZÁLEZ-ASEGUINOLAZA, Y. NAKAYA, A. MOLANO, E. DY, M. ESTEBAN, D. RODRÍGUEZ, J.R. RODRÍGUEZ, P. PALESE, A. GARCÍA-SASTRE & R.S. NUSSENZWEIG: Induction of protective immunity against malaria by priming/boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8(+)- T-cell epitope derived from the circumsporozoite protein of Plasmodium yoelii. Journal of Virology, 77, 11859-11866 (2003).

C.F. BASLER, A. MIKULASOVA, L. MARTINEZ-SOBRIDO, J. PARAGAS, E. MÜHLBERGER, M. BRAY, H.-D. KLENK, P. PALESE & A. GARCÍA-SASTRE: The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. Journal of Virology, 77, 7945-7956 (2003).

Y. NAKAYA, H. ZHENG & A. GARCÍA-SASTRE: Enhanced cellular immune responses to SIV Gag by immunization with influenza and vaccinia virus recombinants. Vaccine, 21, 2097-2106 (2003).

S.V. BOURMAKINA & A. GARCÍA-SASTRE: Reverse genetics studies on the filamentous morphology of influenza A virus. Journal of General Virology, 84, 517-527 (2003).

X. WANG, C.F. BASLER, B.R.G. WILLIAMS, R.H. SILVERMAN, P. PALESE & A. GARCÍA-SASTRE: Functional replacement of the carboxy-terminal two thirds of the influenza A virus NS1 protein with short heterologous dimerization domains. Journal of Virology, 76, 12951-12962 (2002).

G.K. GEISS, M. SALVATORE, T.M. TUMPEY, V.S. CARTER, X. WANG, C.F. BASLER, J.K. TAUBENBERGER, R.E. BUMGARNER, P. PALESE, M.G. KATZE & A. GARCÍA-SASTRE: Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proceedings of the National Academy of Sciences (U.S.A.), 99, 10736 10741 (2002).

P. PALESE & A. GARCÍA-SASTRE: Influenza vaccines: present and future. The Journal of Clinical Investigation, 110, 9-13 (2002).

R. MORA, E. RODRIGUEZ-BOULAN, P. PALESE & A. GARCÍA-SASTRE: Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal. Journal of Virology, 76, 3544-3553 (2002).

M. SALVATORE, C.F. BASLER, J.-P. PARISIEN, C.M. HORVATH, S. BOURMAKINA, H. ZHENG, T. MUSTER, P. PALESE & A. GARCÍA-SASTRE: Effects of influenza A virus NS1 protein on protein expression: The NS1 protein enhances translation and is not required for shutoff of host protein synthesis. Journal of Virology, 76, 1206-1212 (2002).

T. NAKAYA, J. CROS, M-S. PARK, Y. NAKAYA, H. ZHENG, A. SAGRERA, E. VILLAR, A. GARCÍA-SASTRE & P. PALESE: Recombinant Newcastle disease virus as a vaccine vector. Journal of Virology, 75, 11868-11873 (2001).

D.E. LEVY & A. GARCÍA-SASTRE: The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews, 12, 143-156 (2001).

C.F. BASLER, A.H. REID, J.K. DYBING, T.A. JANCZEWSKI, T.G. FANNING, H. ZHENG, M. SALVATORE, M.L. PERDUE, D.E. SWAYNE, A. GARCÍA-SASTRE, P. PALESE & J.K. TAUBENBERGER: Sequence of the 1918 pandemic influenza virus non-structural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proceedings of the National Academy of Sciences (U.S.A.), 98, 2746-2751 (2001).
This article was highlighted in the journal cover and was accompanied by the following commentary: J. Lederberg: H1N1-influenza as Lazarus: Genomic resurrection from the tomb of an unknown.

A. GARCÍA-SASTRE: Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative strand RNA viruses. Virology, 279, 375-384 (2001).

H. ZHENG, P. PALESE & A. GARCÍA-SASTRE: Antitumor properties of influenza virus vectors. Cancer Research, 60, 6972 6976 (2000).

X. WANG, M. LI, H. ZHENG, T. MUSTER, P. PALESE, A.A. BEG & A. GARCÍA-SASTRE: Influenza A virus NS1 protein prevents the activation of NF-kappaB and induction of alpha/beta interferon. Journal of Virology, 74, 11566-11573 (2000).

J. TALON, C.M. HORVATH, R. POLLEY, C.F. BASLER, T. MUSTER, P. PALESE & A. GARCÍA-SASTRE: Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. Journal of Virology, 74, 7989-7996 (2000).

J. TALON, M. SALVATORE, R. E. O’NEILL, Y. NAKAYA, H. ZHENG, T. MUSTER, A. GARCÍA-SASTRE & P. PALESE: Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proceedings of the National Academy of Sciences (U.S.A.), 97, 4309-4314 (2000).

E. FODOR, L. DEVENISH, O.G. ENGELHARDT, P. PALESE, G.G. BROWNLEE & A. GARCÍA-SASTRE: Rescue of influenza A virus from recombinant DNA. Journal of Virology, 73, 9679-9682 (1999).

H. ZHENG, H.A. LEE, P. PALESE & A. GARCÍA-SASTRE: Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication. Journal of Virology, 73, 5240-5243 (1999).

A. GARCÍA-SASTRE, A. EGOROV, D. MATASSOV, S. BRANDT, D.E. LEVY, J.E. DURBIN, P. PALESE & T. MUSTER: Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology, 252, 324-330 (1998).

A. GARCÍA-SASTRE, R.K. DURBIN, H. ZHENG, P. PALESE, R. GERTNER, D.E. LEVY & J.E. DURBIN: The role of interferon in influenza virus tissue tropism. Journal of Virology, 72, 8550-8558 (1998).

N.P. RESTIFO, D.R. SURMAN, H. ZHENG, P. PALESE, S.A. ROSENBERG & A. GARCÍA-SASTRE: Transfectant influenza A viruses are effective recombinant immunogens in the treatment of experimental cancer. Virology, 249, 89-97 (1998).

E. FODOR, P. PALESE, G.G. BROWNLEE & A. GARCÍA-SASTRE: Attenuation of influenza A virus mRNA levels by promoter mutations. Journal of Virology, 72, 6383-6290 (1998).

A. GARCÍA-SASTRE: Negative-strand RNA viruses: applications to biotechnology. Trends in Biotechnology, 16, 230-235 (1998).

S. PLESCHKA, S.R. JASKUNAS, O.G. ENGELHARDT, T. ZÜRCHER, P. PALESE & A. GARCÍA-SASTRE: A plasmid-based reverse genetics system for influenza A virus. Journal of Virology 70, 4188-4192 (1996).

H. ZHENG, P. PALESE & A. GARCÍA-SASTRE: Nonconserved nucleotides at the 3' and 5' ends of an influenza A virus RNA play an important role in viral RNA replication. Virology, 217, 242-251 (1996).