Construction, Analysis and Visualization of a Large-scale Signaling Network in Hippocampal Neuronal Mammalian Cells

Network Statistics

Number of components: 608
Number of interactions: 1427
Number of references: 1298

Types of Molecules Total types of molecules: 43 Receptor: 53 Lipid: 7 Kinase: 89 Cyclase: 4 Ligand: 30 Cytoskeleton: 26 Adapter: 119 Synthase: 2 Vesicle: 21 Channel: 20 Ubiquitinase: 4 GTPase: 13 GAP: 15 GEF: 20 TF: 37 Bcl2Family: 8 Chaperone: 7 DNase: 1 Messenger: 8 Inhibitor: 20 Phosphatase: 19 Activator: 8 Protease: 8 Ion: 3 Matrix: 3 DNA: 4 Ribosome: 10 Elongation: 1 CellAdhesion: 7 Gprotein: 10 Transporter: 2 HDAC: 1 RNA: 2 Antagonist: 1 Peptide: 1 Polymerase: 1 PDE: 11 Pump: 2 Phospholipase: 4 Methylase: 1 Dismutase: 1 Sumo: 3 Hydrolase: 1

Types of Locations Total types of locations: 9 Membrane: 82 Cytosol: 368 Extracellular: 34 Vesicles: 33 Nucleus: 48 Mitochondria: 9 ER: 13 Ribosomes: 21 Effects Total types of effects: 3 +: 764 0: 311 _: 352 Types of Interactions Total types of interactions: 19 Phosphorylation: 323 Binding: 888 Sumolation: 7 Ubiquitination: 11 Dephosphorylation: 66 Generating: 1 GEF: 29 GAP: 21 Deubiquitination: 1 Pumping: 2 Opening: 20 Cleavage: 34 Importing: 2 Synthesis: 9 PDE: 11 Depolymerization: 1 Methylation: 1

Connectivity Distribution

Links per Node	Total Links	In Links	Out Links
1	146	167	223
2	109	86	84
3	100	37	60
4	56	25	29
5	47	19	7
6	43	15	7
7	18	10	3
8	10	7	2
9	11	6	3
10	11	4	2
11	6	4	1
12	8	1	2
13	6	2	0
14	3	1	1
15	8	1	1
16	3	0	2
17	2	0	1
18	2	0	0
19	3	0	2
20	2	1	0
21	1	0	0
22	2	0	0
23	1	0	0
24	0	0	0
25	2	0	0
26	0	0	0
27	1	0	0
28	0	0	0
29	1	0	0
30	1	1	0
31	0	0	0
32	2	0	2
33	0	0	0
34	0	0	0
35	0	0	0
36	0	0	0
37	0	0	0
38	2	0	0
39	0	0	2
40	0	0	0
41	0	0	0
42	2	0	0
43	0	0	0
44	0	0	0
45	0	0	0
46	0	0	2
47	0	0	0
48	0	0	0
49	0	0	0
50	2	0	0

Average links per node: 4.6875
Characteristic Path Length: 4.28937
Clustering Coefficient: 0.110581
Grid Coefficient: 0.0275154