Supplementary Figures

Molecular Basis for Interactions of G Protein bg Subunits with Effectors

Source: Science. 1998 May;280(5367):1271-4.

• Effector Interactions with the b-Subunit of Heterotrimeric G Protein
• Mutations that inhibit stimulation of adenylyl cyclase 2
• Mutations that either enhance (dark color) or inhibit (light color) stimulation of beta-adrenergic receptor kinase
• Mutations that either increase (dark color) or decrease (light color) inhibition of calcium channels
• Mutations that inhibit stimulation of potassium channels
• Mutations that either increase (dark color) or decrease (light color) stimulation of phospholipase C-beta 2
• Residues important for Ga binding
• Residues important for interactions with rhodopsin
• Sidechains of Gb residues implicated in effector binding