|
|
|
|
Hai-Shan
Wu, M. Isabel Fiel, and Joan Gil ------------------------------------------------------------------------------------------------------ Introduction--Hepatic fibrosis is one of the major consequences of liver disease. Quantitative difference exists in the fibrosis between chronic hepatitis C patients and those with alcoholic liver disease. To assess the areas of fibrosis in the study of connective tissue development and regression in livers of small bowel transplant recipients, the images need to be segmented so that fibrosis pixels are recognized and separated from the rest. With Sirius red stains, the regions of perisinusoidal fibrosis along with the scattered liver cells are stained in red color. Results--The degree of fibrosis in liver
biopsies of patients that underwent small bowel transplantation need to be
measured prior to transplant and after the transplant. Usually, the patients
prior to transplant receive long-term total parenteral nutrition which may
lead to severe liver damage as manifested by steatohepatitis, cholestasis and
deposition of perisinusoidal and periportal fibrous tissue deposition. To
quantify the degree of fibrosis that develops in the liver pre- and
post-small bowel transplant, it is needed to segment the area of the fibrosis.
(more
details coming soon …) (Click
on images for the full sized images)
|
|
|
