Volume 66 Number 2 March 1999	back to contents

Hepatocellular Carcinoma with Fibrolamellar Pattern in a Patient with Autoimmune Cholangitis	109 - 112
Regina C. Singson, M.D.1, Mark Fraiman, M.D.2, And Stephen A. Geller, M.D.1
From the 1Department of Pathology and Laboratory Medicine, and 2Division of Liver and Pancreas Transplantation of the Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048. Address correspondence to Stephen A. Geller, M.D., Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.

ABSTRACT
A 75-year-old woman with a 15-year history of autoimmune cholangitis underwent orthotopic liver transplantation because of progressive liver decompensation. A clinically unsuspected hepatocellular carcinoma was found. A portion of the tumor showed fibrolamellar differentiation. Hepatocellular carcinoma, either with the usual pattern or with a fibrolamellar pattern, is rare in the setting of primary biliary cirrhosis, but has been seen in the setting of autoimmune hepatitis. Autoimmune cholangitis is a relatively recently recognized form of autoimmune liver disease whose association with hepatocellular carcinoma has yet to be determined.

KEY WORDS
Autoimmune cholangitis, primary biliary cirrhosis, hepatocellular carcinoma, fibrolamellar hepatocellular carcinoma

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