Mount Sinai Journal of Medicine - Volume 66, Number 5&6, Page 330

Volume 66 Number 5&6
October/November 1999 back to contents

Transient Headache and Impaired Vision after Intravenous Thyrotropin-Releasing Hormone
in a Patient with Pituitary Macroadenoma 330-333

Issac Sachmechi, M.D., Rachelle N. Bitton, M.D., Dineshkumar Patel, M.D., and Bruce S. Schneider, M.D.

Address correspondence to Issac Sachmechi, M.D., F.A.C.P., F.A.C.E., Department of Medicine, Room B-313, Division of Endocrinology and Metabolism, Mount Sinai Services at Queens Hospital Center, 82-68 164 Street, Jamaica, NY 11432.

ABSTRACT
We report a case of transient headache and impaired vision following administration of intravenous thyrotropin-releasing hormone (TRH) to a woman with a non-functioning pituitary macroadenoma, visual field defect, and elevated thyroid-stimulating hormone (TSH). The symptoms lasted for two hours and then resolved without known sequelae. There are a few other reported cases of similar adverse reactions to neuroendocrine manipulation in patients with pituitary macroadenomas. This is the second reported case of such adverse reactions to TRH alone and the first in which the patient had prior elevation of TSH.

KEY WORDS
Thyrotropin-releasing hormone, pituitary macroadenoma, headache, primary hypothyroidism, impaired vision

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Volume 66 Number 5&6 October/November 1999	back to contents

Transient Headache and Impaired Vision after Intravenous Thyrotropin-Releasing Hormone in a Patient with Pituitary Macroadenoma	330-333
Issac Sachmechi, M.D., Rachelle N. Bitton, M.D., Dineshkumar Patel, M.D., and Bruce S. Schneider, M.D.
Address correspondence to Issac Sachmechi, M.D., F.A.C.P., F.A.C.E., Department of Medicine, Room B-313, Division of Endocrinology and Metabolism, Mount Sinai Services at Queens Hospital Center, 82-68 164 Street, Jamaica, NY 11432.