Volume 68 Numbers 4 & 5 September / October 2001	back to contents

Cutaneous Granulomas Masquerading as Tuberculoid Leprosy in a Patient with Congenital Combined Immunodeficiency	326–330
Amy I. Krupnick, M.D., Helen Shim, M.D., Robert G. Phelps, M.D., Charlotte Cunningham-Rundles, M.D., Ph.D., and Allen N. Sapadin, M.D.
Address correspondence to Allen N. Sapadin, M.D., Department of Dermatology, Box 1047, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029.

ABSTRACT
Combined immunodeficiency disorders are characterized by abnormalities in cellular and humoral immunity. This classification includes common variable immunodeficiency (CVI), a primary immunodeficiency disorder characterized by hypogammaglobulinemia, recurrent bacterial infections, and significant T-cell abnormalities. Associated autoimmune diseases include rheumatoid arthritis, pernicious anemia, idiopathic thrombocytopenic purpura, and systemic lupus erythematous. Granulomatous lesions in lymphoid tissues, solid organs, and skin have been reported. We describe a patient with CVI who developed cutaneous granulomas with perineural invasion; to our knowledge, this is a previously undescribed feature.

KEY WORDS
Tuberculoid leprosy, cutaneous granulomas, immunodeficiency

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