Volume 68 Number 6 November 2001	back to contents

Castleman's Disease and Superior Vena Cava Thrombi: A Rare Presentation and a Review of the Literature	410-416
Hemant Dhingra, M.D.1, Damanpaul Sondhi, M.D.1, Jean Fleischman, M.D.2,3, Raji Ayinla, M.D.4,5, Kiran Chawla, M.D.6,7, and Fred Rosner, M.D.8,9
From Mount Sinai Services at Queens Hospital Center, Jamaica, NY and Mount Sinai School of Medicine, New York, NY. 1Resident, 2Associate Director, and 8Director, Department of Medicine, 4Attending Physician, Pulmonary and Critical Care Division, and 6Associate Director, Department of Radiology, Mount Sinai Services at Queens Hospital Center, Jamaica, NY; and 3Clinical Associate Professor of Medicine, 5Instructor of Medicine, 7Assistant Professor of Radiology, and 9Professor of Medicine, Mount Sinai School of Medicine, New York, NY. Address correspondence to Fred Rosner, M.D., Department of Medicine, Queens Hospital Center, 82-68 164th Street, Jamaica, NY 11432.

ABSTRACT
Castleman's disease is a clinicopathological entity in which growth of lymphoid tissue is unregulated. It may present as asymptomatic involvement of one lymph node group or as a multicentric disease with systemic symptoms. Unlike localized disease, for which surgical excision is curative regardless of the histological type, multicentric disease often necessitates aggressive systemic therapy and portends a poor outcome. Superior vena caval thrombosis is an uncommon manifestation associated with Castleman's disease.

We describe a patient with this rare manifestation and present a systematic survey of the disease, based on the current literature.

KEY WORDS
Castleman's disease, Kaposi's sarcoma, superior vena cava thrombosis.

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