Volume 70 Number 3 May 2003	back to contents

From the Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY.

Address all correspondence to Jeffrey Alexis, M.D., Department of Medicine, Box 1030, Mount Sinai School of Medicine, New York, NY 10029; e-mail: jeffrey.alexis@mssm.edu

Adapted from a Grand Rounds presentation to the Department of Medicine, Mount Sinai School of Medicine, New York, NY on February 15, 2000 and updated as of October 2002.

ABSTRACT

Transplant arteriopathy is the leading cause of long-term morbidity and mortality following heart transplantation. The pathologic hallmark of this disease is intimal proliferation. Animal models have demonstrated that immunologic factors, including cytokines, cellular adhesion molecules and inflammatory cells, play a significant role in the development of this arteriopathy. One goal of future studies will be to translate findings in animal models into effective treatments in humans.

KEY WORDS

Transplantation, arteriopathy, intimal proliferation, immune system, cytokine, chemokine.

MSSM Home

Back Issues | Indexes | Search | Journal Home