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| Volume 70 Number 4 September 2003 |
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| General Articles A Rare Cause of Pituitary Stalk Enlargement and Panhypopituitarism |
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1 Division of Endocrinology and Metabolism, Johns Hopkins UniversitySchool
of Medicine, Bayview Medical Center, and
2SEMPR — Serviço de Endocrinologia e Metabologia do Hospital
de Clínicas da Universidade Federal do Paraná, Curitiba,
Brazil.
Address all correspondence to Shehzad Basaria, M.D., 4940 Eastern Avenue, B-Building, Suite 114, Baltimore, MD 21224; Email: sbasaria@jhmi.edu.
Accepted for publication December 2002.
ABSTRACT
Pituitary stalk involvement is seen in a variety of medical conditions such as infectious diseases, infiltrative diseases and tumors (intracranial and metastatic). Metastatic cancer has a greater propensity to involve the infundibulum and neurohypophysis. We report a case of a 68-year-old man who presented with thickening of the stalk, panhypopituitarism, diabetes insipidus and generalized lymphadenopathy.Lymphoma was diagnosed on axillary lymph node biopsy and lymphomatous involvement of the infundibulum was suspected. Although infundibular thickening resolved and diabetes insipidus improved after chemotherapy, panhypopituitarism persisted.
KEY WORD
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