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| Volume 72 Number 2 March 2005 |
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Mesalamine-Induced Lung Injury in a Patient with Ulcerative Colitis and a Confounding Autoimmune Background: A Case Report |
136-140 |
Giovanni C Actis, M.D. 1 , Antonio Ottobrelli, M.D. 1 , Sergio Baldi, M.D. 2 , Ermanno Scappaticci, M.D. 2 , Vittorio Modena, M.D. 3 , Enrico Fusaro, M.D. 3 , Giulio Mengozzi, M.D. 4 , and Mario Rizzetto, M.D. 1 |
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From the 1 Department of Gastroenterology, Divisions of 2 Pneumology and 3 Rheumatology and 4 Clinical Chemistry Laboratory, Ospedale Molinette, Torino , Italy.
Address all correspondence to Giovanni C. Actis, M.D., Department of Gastroenterology, Ospedale Molinette , Corso Bramante 88, 10126 Torino, Italy;
e-mail: actis_g@libero.it
Accepted for publication October 2004.
ABSTRACT
Two years after being diagnosed with ulcerative colitis, a 57-year-old man taking oral mesalamine experienced severe respiratory distress due to left lung pleuropneumonitis. Eight months later, severe respiratory distress recurred due to right lung pneumonitis. Extraintestinal manifestations of inflammatory bowel disease or mesalamine-induced pulmonary injury were considered in the differential diagnosis, which was complicated by a history of aseptic meningitis and evidence of an ongoing autoimmune response. The implications of the case are discussed.
KEYWORDS
Inflammatory bowel disease, lung injury, autoimmunity.
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