The Mount Sinai Journal of Medicine

 

Volume 72 Number 5
September 2005		 back to contents

Dean's Lecture
Probing the Onset and Regulation of Erythroid Cell-Specific Gene Expression

 333-338
James J. Bieker, Ph.D.

Address all correspondence to James J. Bieker, Ph.D., Box 1020, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029.

Adapted from a Dean's Lecture presentation at the Mount Sinai School of Medicine, New York, NY on June 23, 2004, and updated as of March 2005.

ABSTRACT

Cell-restricted transcriptional modulators play a crucial role in the process of selective gene regulation during hematopoiesis. Erythroid Krüppel-like factor (EKLF; KLF1) is a transcription factor, originally identified in this laboratory, which plays a crucial role as a transcriptional activator at the adult ß-globin locus. This review will describe a subset of experiments and approaches related to deciphering its mechanism of action and the means by which it itself is induced.

KEY WORDS

Transcription, EKLF, erythroid cell, gene regulation.

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