Volume 73 Number 2 March 2006	back to contents

From the Erciyes University Medical Faculty, Department of Anesthesiology and Reanimation Intensive Care , Kayseri, Turkey.

Address all correspondence to A ynur Akin, M.D., Alpaslan Mah. Kandilli Sok. Bezciler sitesi 3.blok No: 6/11, 38030 Kayseri, Turkey; e -mail: aaynur@erciyes.edu.tr

Accepted for publication May 2005.

ABSTRACT

Purpose: To evaluate the efficacies of tropisetron and tropisetron-propofol combination in the prophylaxis for postoperative nausea and vomiting in patients undergoing thyroidectomy under desflurane anesthesia. (This combination has apparently not been previously investigated for this particular surgery and anesthesia.)

Methods: Prospective, randomized, double-blind study. One hundred five patients aged between 19 and 68 years were included in the study. Group T received 5 mg of tropisetron (tropisetron group. n=35), group TP (tropisetron-propofol group, n=35) received 5 mg of tropisetron and 0.5 mg/kg of propofol and group P (placebo group, n=35) received saline, immediately after anesthesia induction. The anesthesia induction regimen was applied to all patients, and anesthesia was maintained with 5–7% desflurane and 66% N 2 O in O 2 .

Results: Group TP reported a lower incidence of postoperative nausea and vomiting (17%) than those in groups T and P (42.8% and 77%, respectively). The postoperative antiemetic requirements were significantly higher in the placebo group compared to the other two groups (p<0.05).

Conclusion: The tropisetron-propofol combination is more effective than tropisetron alone in the prevention of postoperative nausea and vomiting after thyroidectomy.

KEY WORDS

Side effects, postoperative, nausea, vomiting, antiemetic, tropisetron, propofol, surgery, thyroidectomy, anesthetics, desflurane.

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