The Mount Sinai Journal of Medicine

 

Volume 73 Number 5
September 2006		 back to contents
Decrease of Total Antioxidant Capacity during Coronary Artery Bypass Surgery 777-783
Alper Sami Kunt, M.D.1, Sahbettin Selek, M.D.2, Hakim Celik, M.S.2, Deniz Demir, M.D.1, Ozcan Erel, M.D.2, and Mehmet Halit Andac, M.D.1

Department of 1Cardiovascular Surgery and 2Biochemistry, Harran University Research Hospital, Sanliurfa, Turkey.

Address all correspondence to Alper Sami Kunt, M.D., Department of Cardiovascular Surgery, Harran University, Research Hospital, TR-63100 Sanliurfa, Turkey; e-mail: dralper@msn.com

Accepted for publication September 2005.

Abstract

Objective: Cardiac surgery induces an oxidative stress, which may lead to impairment of cardiac function. In this study, we aimed to measure the changes of oxidative and antioxidative status of patients undergoing coronary artery bypass surgery (CABG).

Materials and Methods: We studied 79 patients who underwent CABG with and without cardiopulmonary bypass (CPB). Of the 79 patients, 39 had CPB and 40 did not. Blood samples were drawn before, during, and after the surgery. Antioxidant status was evaluated by measuring total antioxidant capacity (TAC), and oxidative status was evaluated by measuring total peroxide (TP) levels and oxidative stress index (OSI).

Results: TP and OSI levels increased, while TAC decreased progressively after the beginning of surgery, for all patients. There were negative correlations between TAC levels and aortic cross-clamping period and anastomosis time ( r = -0.553, p < 0.001 and r = -0.500, p < 0.001, respectively). In addition, there was a positive correlation between TAC and ejection fraction (r = 0.647, p < 0.001).

Conclusions: During CABG, oxidant and OSI levels significantly increase and TAC significantly decreases. This situation is influenced by long CPB and anastomosis time, and also by low ventricular ejection fraction. We concluded that the patients who undergo CABG are exposed to potent oxidative stress that impairs their TAC. We speculate that supplementation with antioxidant vitamins such as vitamins C and E may be beneficial for patients undergoing CABG.

Key Words

Antioxidant capacity, cardiac surgery, coronary artery bypass grafting, oxidative stress.

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