Physician/Scientist

The Biochemical Defect in
Types A and B Niemann-Pick Disease

Sphingomyelin Chemistry and Metabolism

• Sphingomyelin Chemistry
• Sphingomyelin Synthesis
• Sphingomyelin Degradation
• Acid Sphingomyelinase
• Other Mammalian Sphingomyelinases
• Relationship between Intracellular and Secreted ASM
• Overexpression of Human ASM in Chinese Hamster Ovary Cells

The Biochemical Abnormalities in Types A and B NPD

• The Accumulating Lipids
• The Enzymatic Defect