Predoctoral Training in Pharmacology

Integrated Predoctoral Training Program in
Pharmacological Sciences

Pharm Forum

The Pharmacology Journal Club is a part of the Integrated Training Program in Pharmacological Sciences. The club meets biweekly with papers presented by the graduate students. The setting is informal and lunch is provided. Each paper is chosen by the presenting student and usually reflects some aspect of pharmacology/therapeutics in a broad sense. Topics discussed over the past year include general studies on signaling/development to biofilms, opioid receptor trafficking, and therapeutic approaches to HIV. The papers are distributed as PDF files by e-mail a few days before the meeting.

Papers Discussed in Pharm Forum 2008-2009

Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin NE, Langston MA, Threadgill DW, Manly KF, Williams RW. 2005. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37:233-242.

Comoletti D, Grishaev A, Whitten AE, Taylor P, Trewhella J. 2008. Characterization of the solution structure of a neuroligin/beta-neurexin complex. Chemico-Biological Interactions 175:150-155.

Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. 2006. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312:117-121.

Hong JW, Studer V, Hang G, Anderson WF, Quake SR. 2004. A nanoliter-scale nucleic acid processor with parallel architecture. Nat. Biotechnol. 22:435-439.

Jarvis SE, Zamponi GW. 2007. Trafficking and regulation of neuronal voltage-gated calcium channels. Curr. Opin. Cell Biol. 19:474-482.

Köhler S, Bauer S, Horn D, Robinson PN. 2008. Walking the interactome for prioritization of candidate disease genes. Am J Hum. Genet. 82:949-958.

Lee SP, So CH, Rashid AJ, Varghese G, Cheng R, Lança AJ, O'Dowd BF, George SR. 2004. Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. J Biol. Chem. 279:35671-35678.

Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G. 2009. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 457:1146-1149.

Majewski M, Betz O, Ochsner PE, Liu F, Porter RM, Evans CH. 2008. Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Gene Ther 15:1139-1146.

Méndez-Ferrer S, Lucas D, Battista M, Frenette PS. Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452:442-447.

Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. 2008. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 133:666-680.

Ostrowski SM, Wilkinson BL, Golde TE, Landreth G. 2007. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J Biol. Chem. 282:26832-26844.

Schug TT, Berry DC, Shaw NS, Travis SN, Noy N. 2007. Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 129:723-733.

Suzuki H, Tabata K, Kato-Yamada Y, Noji H, Takeuchi S. 2004. Planar lipid bilayer reconstitution with a micro-fluidic system. Lab Chip. 4:502-505.

Torres R, Herrerias A, Serra-Pagès M, Roca-Ferrer J, Pujols L, Marco A, Picado C, de Mora F. 2008. An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice. Respir. Res 9:72.

Urigüen L, Berrendero F, Ledent C, Maldonado R, Manzanares J. 2005. Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. Eur. J Neurosci. 22:2106-2110.