Alessia Baccarini, PhD
- ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Research Topics:Cancer, Gene Regulation, Molecular Biology, Oncogenes, RNA
Dr. Alessia Baccarini is an Assistant Professor in the Department of Genetics and Genomic Sciences. She trained in molecular biology and biotechnology at the University of Rome and Harvard Medical School; where she focused on the role of YAP in DNA damage and cancer. She joined Mount Sinai in 2008, and led studies that uncovered one of the first known factors to control microRNA turnover and decay. She subsequently helped lead work on the first microRNA decoy and sensor vector libraries, and developed a new high-throughput approach, called Sensor-seq, which enables genome-wide measure of microRNA activity. She used the microRNA sensor library to determine the quantitative relationship between a microRNA’s concentration and its capacity for target suppression. These studies led to the finding that microRNAs only function above a threshold concentration, and that there is widespread post-transcriptional regulation of microRNA activity. She is now investigating the functions of non-coding RNAs in cancer biology.
BSc, La Sapienza di Roma
PhD, La Sapienza di Roma
Paola Campese Award for Leukemia Research
Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM. TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. Cell 2014 Jul; 158(3).
Parikh A, Lee C, Joseph P, Marchini S, Baccarini A, Kolev V, Romualdi C, Fruscio R, Shah H, Wang F, Mullokandov G, Fishman D, D'Incalci M, Rahaman J, Kalir T, Redline RW, Brown BD, Narla G, DiFeo A. microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition. Nature communications 2014; 5.
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD. The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nature immunology 2014 Jan; 15(1).
Mullokandov G *, Baccarini A *, Ruzo A *, Jayaprakash AD, Tung N, Israelow B, Evans MJ, Sachidanandam R, Brown BD. High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nature methods 2012 Aug; 9(8).
Baccarini A, Chauhan H, Gardner TJ, Jayaprakash AD, Sachidanandam R, Brown BD. Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells. Current biology : CB 2011 Mar; 21(5).
Baccarini A, Brown BD. Monitoring microRNA activity and validating microRNA targets by reporter-based approaches. Methods in molecular biology (Clifton, N.J.) 2010; 667.
Brown BD, Gentner B, Cantore A, Colleoni S, Amendola M, Zingale A, Baccarini A, Lazzari G, Galli C, Naldini L. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nature biotechnology 2007 Dec; 25(12).
Strano S, Monti O, Pediconi N, Baccarini A, Fontemaggi G, Lapi E, Mantovani F, Damalas A, Citro G, Sacchi A, Del Sal G, Levrero M, Blandino G. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Molecular cell 2005 May; 18(4).