David E Burstein, MD
- PROFESSOR | Pathology
- PROFESSOR | Oncological Sciences
MD, Harvard Medical School
Residency, Internal Medicine, Mount Auburn Hospital
Residency, Pathology, NYU Medical Center
Fellowship, Neuropathology, Children's Hospital Boston
Fellowship, Cytopathology, Montefiore Medical Center
We are conducting both basic and applied research in the biology of cancer cells. We are investigating the clinical utility of three tumor marker: 1) phosphorylated histone H1 (collaboration with Dr. Kohtz, Pathology); 2) glucose transporter GLUT-1 (collaboration with Dr. Haber, Medicine); 3) a ras-oncogene-induced 31kd vesicle protein (collaboration with Dr.Hanson, Pathology). These markers appear to be of clinical value in the diagnosis and management of colon, ovarian, and breast cancer, and in body-cavity effusions. We are investigating applications in these and other malignancies such as bladder carcinoma. We are also investigating mechanisms of tumor growth suppression mediated by growth factors such as nerve growth factor, and by signal transduction-regulating proteins. The aim is to uncover new diagnostic, prognostic and therapeutic advances in cancer and other diseases which result from aberrant cell proliferation.
Rathan A, Weiser KR, Pritsker A, Itzkowitz S, Bodian C, Slater G, Weiss A, Burstein D. GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer 1998 Jul 1; 83(1): 34-40.
Matsushima AY, Strauchen J, Lee G, Scigliano E, Hale EE, Weisse MT, Burstein D, Kamel O, Moore PS, Chang Y. Posttransplantation plasmacytic proliferations related to Kaposi's sarcoma-associated herpesvirus. Am J Surg Pathol 1999; 11: 1393-1400.
Weiser KR, Burstein D, Reder I, Pritsker A. GLUT1 glucose transporter expression in benign and malignant thyroid cells: An immunohistochemical study.;.
Kelman A, Rathan A, Leibowitz J, Burstein D. Thyroid cytology and the risk of malignancy in thyroid nodules: Importance of nuclear atypia in 'indeterminate' specimens.;.
Burstein D, Rathan A, Weiser K, Pritsker A, Itzkowitz S. GLUT-1 glucose transporter: A marker of neoplastic progression in colonic epithelial neoplasms.;.
Goldfischer M, Weiser K, Pritsker A, Burstein D. GLUT-1 glucose transporter expression in ovarian neoplasms: A marker of tumor progression.;.