Harold W Koenigsberg, MD
- PROFESSOR | Psychiatry
Research Topics:Brain Imaging, Imaging, Neuroscience
At a recent meeting of the American Psychoanalytic Association, Dr. Harold Koenigsberg presented new findings about patients with borderline personality disorder (BPD) and the distinct neurological differences between them and healthy individuals. Learn more about this research in Inside Mount Sinai.
Harold W. Koenigsberg, M.D., is Professor of Psychiatry at Mount Sinai School of Medicine. He has had a longstanding research and clinical interest in borderline personality disorder (BPD), is coauthor of two books on the treatment of borderline personality disorder, and has published widely on the neurobiology, phenomenology and treatment of the disorder. He is currently studying the emotional instability characteristic of borderline personality disorder. To better understand the neurobiology of emotional instability, he is using functional magnetic resonance imaging (fMRI) methods to identify brain networks activated as borderline patients process emotional and social stimuli. Dr. Koenigsberg is carrying out this work as principal investigator of a National Institute of Mental Health (NIMH) RO1 grant. He is also studying the role of second messenger systems in emotional instability in BPD. A principal area of his interest is in the interaction between the neurobiologic and psychosocial components of the personality disorders. In addition, Dr. Koenigsberg is principal investigator of an NIMH-funded RO1 neuroimaging study of cognitive processing in schizotypal personality disorders and in schizophrenia.
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Psychiatry, American Board of Psychiatry and Neurology
Multi-Disciplinary Training AreasClinical Research Education Program [CLR], Neuroscience [NEU]
MD, Albert Einstein College of Medicine
Residency, Psychiatry, Bronx Municipal Hospital Center
Fellowship, Inpatient Psych, New York Hospital
- Biological Correlates of Personality Disorder
Results of recent research studies suggest that genetic and biologic factors may greatly influence the development of personality. In order to help patients who have severe disturbances of personality, doctors need to know more about these factors. These studies are intended t...
- An fMRI Study of the Enhancement of Emotion Regulation in Borderline Patients
This study explores what causes borderline patients to have emotional lability. One possible cause is that they are unable to employ thinking strategies to emotionally distance themselves from distressing stimuli in the way that healthy controls successfully do. BPD patients m...
- A Pilot fMRI Study to Investigate the Impact of Oxytocin Administration on the Behavioral and Neural Mechanisms of Interpersonal Cooperation in Borderline Personality Disorder and Healthy Adults
The neuropeptide oxytocin has been shown to increase trust, reduce reactivity to emotional stimuli in the amygdala—a limbic brain region associated with negative emotional response— and selectively increase empathy and empathic accuracy in healthy adults. Since impairment in t...
Koenigsberg HW, Fan J, Ochsner KN, Liu X, Guise KG, Pizzarello S, Dorantes C, Guerreri S, Tecuta L, Goodman M, New A, Siever LJ. Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder. Biological psychiatry 2009 Nov; 66(9).
Koenigsberg HW, Siever LJ, Lee H, Pizzarello S, New AS, Goodman M, Cheng H, Flory J, Prohovnik I. Neural correlates of emotion processing in borderline personality disorder. Psychiatry research 2009 Jun; 172(3).
Koenigsberg HW. Affective instability: toward an integration of neuroscience and psychological perspectives. Journal of personality disorders 2010 Feb; 24(1).
Koenigsberg HW, Siever LJ. Borderline personality disorder . In: New encyclopedia of neuroscience, Squire L, Albright T, Bloom F,Gage F, & Spitzer N (Eds). Elsevier;.
Koenigsberg HW, Woo-Ming AM, Siever LJ, Nathan PR, Gorman JM (Eds). Psychopharmacological treatment of personality disorders. In: A guide to treatments that work, 3rd edition. New York: 2007, Oxford University Press;.
Koenigsberg HW, Harvey PD, Mitropoulou V, Schmeidler J, New AS, Goodman M, Silverman J, Serby M, Schopick F, Siever LJ. Characterizing affective instability in borderline personality disorder. Am J Psychiatry 2002; 159: 784-88.
Koenigsberg HW, Kernberg OF, Stone MH, Appelbaum AH, Yeomans FE, Diamond D. Borderline patients: extending the limits of treatability. New York: 2000, Basic Books; 2000.
Koenigsberg HW, Buchsbaum MS, Buchsbaum BR, Schneiderman JS, Tang CY, New A, Goodman M, Siever LJ. Functional MRI of visuospatial working memory in schizotypal personality disorder: a region-of-interest analysis. Psychol Med 2005 Jul; 35(7): 1019-1030.
Koenigsberg HW, Reynolds D, Goodman M, New AS, Mitropoulou V, Trestman R, Silverman J, Siever LJ. Risperidone in the treatment of schizotypal personality disorder. J Clin Psychiatry 2003; 64: 628-34.
Koenigsberg HW, Teicher MH, Mitropoulou V, Navalta C, New AS, Trestman R, Seiver LJ. 24-Hour monitoring of plasma norepinephrine, MHPG, cortisol, growth. J Psychiatr Res 2004; 38: 503-11.