Kirsten Sadler Edepli

  • ASSISTANT PROFESSOR Liver Diseases
  • ASSISTANT PROFESSOR Developmental and Regenerative Biology
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Education

  • fellowship, Massachusetts Institute of Technology
    Liver development and regeneration in zebrafish, Nancy Hopkins Laboratory

  • B.A., Mount Holyoke College
    Biology and Anthropology

  • M.M.Sc., Harvard Medical School
    Markey Scholar Program

  • Ph.D., Harvard University
    Cell and Developmental Biology

Biography

Awards

  • 2009 -
    Harold and Golden Lamport Award
    Mount Sinai School of Medicine

  • 2008 - 2011
    Basil O'Connor Starter Scholar Award
    March of Dimes

  • 2008 - 2011
    Research Scholar Award
    American Gastroenterological Association

Research

Dr. Sadler-Edepli is the Director of the Zebrafish Models of Liver Disease Laboratory and the Model Co-Core Director of the Mount Sinai Alcoholic Liver Disease Research Center. 

Specific Clinical/Research Interest: Using zebrafish to understand liver development, regeneration and disease.

Students: Raksha Mudbhary, Dru Imrie, Vinitha Jacob, Brandon Kent (co-mentored with Dr. Martin Walsh)

Postdoctoral Fellows: Deanna Howarth, Ana Vacaru, Orkhontuya Tsedensodnom

Research Personnel: Alex Mir, Meghan Walsh

Faculty: Jaime Chu

Current Research Focus
Using zebrafish to understand liver development, regeneration and disease

Zebrafish are an excellent model for studying embryonic development and we are using the power of zebrafish genetics to define genes required for liver growth as well as to identify new models of liver diseases. Fatty liver disease is emerging as an important liver pathology and is typically associated with obesity and type II diabetes and together these comprise Metabolic Syndrome, which affects nearly 5 percent of the American population. We have found a zebrafish mutant that develops fatty liver disease in the embryo, and have named it foie gras (fgr). The foie gras gene is well conserved in animals, but has no assigned sequence or motif that suggest its function. The primary focus of the Sadler Edepli lab is to understand the cellular function of foie gras, and to use the fgr mutant embryo as a model for studying fatty liver disease.

The second focus of our lab is to determine the genetic basis for liver growth in the embryo and during regeneration in adults, and is aimed at testing the hypothesis that a similar program may be responsible for growth control in both circumstances. We have carried out a screen to identify zebrafish mutant embryos which fail to undergo liver growth and are testing the genes responsible for the embryonic phenotype for their role in liver regeneration following partial hepatectomy.

Current Research Studies

- Investigating the role of the unfolded protein response in fatty liver disease

- Identifying the pathways required for  to steatosis due to acute alcohol exposure.

- Discovering the function of the Foie gras protein.

- Understanding the role of UHRF1 in liver growth, regeneration and cancer.

- Determining how UHRF1 is regulated by phosphorylation.

Publications

Cinaroglu A, Gao C, Imrie D, Sadler KC. Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish. Hepatology (Baltimore, Md.) 2011 Apr;.

Howarth DL, Passeri M, Sadler KC. Drinks like a fish: using zebrafish to understand alcoholic liver disease. Alcoholism, clinical and experimental research 2011 May; 35(5).

Mudbhary R, Sadler KC. Epigenetics, development, and cancer: Zebrafish make their MARK. Birth defects research. Part C, Embryo today : reviews 2011 Jun; 93(2).

Imrie D, Sadler KC. White adipose tissue development in zebrafish is regulated by both developmental time and fish size. Developmental Dynamics 2010; 239(11): 3013-.

Zhao X, Monson C, Gao C, Gouon-Evans V, Matsumoto N, Sadler KC, Friedman SL. Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells. Developmental biology 2010 Aug; 344(1).

Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D. The role of insulin receptor signaling in zebrafish embryogenesis. Endocrinology 2008; 149: 5996-6005.

Passeri M, Cinaroglu A, Gao C, Sadler KC. Hepatic Steatosis in Response to Acute Alcohol Exposure in Zebrafish Depends Upon SREBP Activation. Hepatology 2008; 49.

Sadler KC, Krahn KN, Gaur NA, Ukomadu C. Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1. Proc Natl Acad Sci U S A 2007; 104: 1570-1575.

Sadler-Edepli KC, Amsterdam A, Soroka C, Boyer J, Hopkins N. A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Development 2005 Aug; 132(15): 3561-72.

Industry Relationships

Physicians and scientists on the faculty of Mount Sinai School of Medicine often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Sadler Edepli did not report having any of the following types of financial relationships with industry during 2011 and/or 2012: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://www.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Address

Annenberg Building Floor 25 Room 25-26B (office); 30 (lab)
1468 Madison Avenue
New York, NY 10029

Tel: 212-241-7152
Address

Annenberg Building Floor 25 Room 25-30 (lab);
1468 Madison Avenue
New York, NY 10029

Tel: 212-241-0227