M. Cecilia Berin, PhD
- ASSOCIATE PROFESSOR | Pediatrics
Research Topics:Allergy, Antigen Presentation, Cellular Immunity, Chemokines, Cytokines, Dendritic Cells, Epithelial Cells, Immunology, Inflammation, Knockout Mice, Mucosal Immunology, T Cells
Multi-Disciplinary Training AreaImmunology [IMM]
BSc(Hons), Queen's University
MSc, Queen's University
PhD, McMaster University
Postdoctoral, University of California, San Diego
Our laboratory is dedicated to understanding the mucosal immunology of food allergic disorders. Themes within this work include (1) understanding mechanisms responsible for development of sensitization and tolerance to food proteins, (2) determining how allergen-specific T cells home to the gut and induce disease, and (3) finding methods to modify the allergen-specific T cell response for therapeutic purposes. Much of our lab’s work to date has focused on the communication between gastrointestinal epithelial cells, dendritic cells, and antigen-specific T cells in the context of food allergy.
Tordesillas L, Mondoulet L, Blazquez AB, Benhamou PH, Sampson HA, Berin MC. Epicutaneous immunotherapy induces gastrointestinal LAP(+) regulatory T cells and prevents food-induced anaphylaxis. The Journal of allergy and clinical immunology 2016 Jun;.
Benedé S, Blázquez AB, Chiang D, Tordesillas L, Berin MC. The rise of food allergy: Environmental factors and emerging treatments. EBioMedicine 2016 May; 7.
Rahman AH, Tordesillas L, Berin MC. Heparin reduces nonspecific eosinophil staining artifacts in mass cytometry experiments. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2016 Apr;.
Tobar S, Tordesillas L, Berin MC. Triclosan promotes epicutaneous sensitization to peanut in mice. Clinical and translational allergy 2016 Apr; 6.
Berin MC, Shreffler WG. Mechanisms Underlying Induction of Tolerance to Foods. Immunology and allergy clinics of North America 2016 Feb; 36(1).
Gregory JA, Shepley-McTaggart A, Umpierrez M, Hurlburt BK, Maleki SJ, Sampson HA, Mayfield SP, Berin MC. Immunotherapy using algal-produced Ara h 1 core domain suppresses peanut allergy in mice. Plant biotechnology journal 2016 Jan;.
Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, Sampson HA, Berin MC. Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance. PloS one 2015 Dec; 10(12).
Berin MC. Pathogenesis of IgE-Mediated Food Allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2015 Jul;.
Chiang D, Berin MC. An Examination of Clinical and Immunologic Outcomes in Food Allergen Immunotherapy by Route of Administration. Current allergy and asthma reports 2015 Jun; 15(6).
Berin MC. Immunopathophysiology of food protein-induced enterocolitis syndrome. The Journal of allergy and clinical immunology 2015 Mar;.
Järvinen KM, Suárez-Fariñas M, Savilahti E, Sampson HA, Berin MC. Immune factors in breast milk related to infant milk allergy are independent of maternal atopy. The Journal of allergy and clinical immunology 2014 Dec;.
Tordesillas L, Goswami R, Benede S, Grishina G, Dunkin D, Jarvinen KM, Maleki SJ, Sampson HA, Berin MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. The Journal of clinical investigation 2014 Oct;.
Mathern DR, Laitman LE, Hovhannisyan Z, Dunkin D, Farsio S, Malik TJ, Roda G, Chitre A, Iuga AC, Yeretssian G, Berin MC, Dahan S. Mouse and human Notch-1 regulate mucosal immune responses. Mucosal immunology 2014 Jul; 7(4).
Leonard SA, Martos G, Wang W, Nowak-Węgrzyn A, Berin MC. Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa. The Journal of allergy and clinical immunology 2012 Jun; 129(6).
Berin MC, Wang W. Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity. Mucosal immunology 2012 Jun;.
Berin MC, Sicherer S. Food allergy: mechanisms and therapeutics. Current opinion in immunology 2011 Dec; 23(6).
Dunkin D, Berin MC, Mayer L. Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. The Journal of allergy and clinical immunology 2011 Dec; 128(6).
Blázquez AB, Mayer L, Berin MC. Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. Gastroenterology 2010 Oct; 139(4).
Blázquez AB, Knight AK, Getachew H, Bromberg JS, Lira SA, Mayer L, Berin MC. A functional role for CCR6 on proallergic T cells in the gastrointestinal tract. Gastroenterology 2010 Jan; 138(1).
Berin MC, Mayer L. Immunophysiology of experimental food allergy. Mucosal immunology 2009 Jan; 2(1).
Berin MC, Shreffler WG. T(H)2 adjuvants: implications for food allergy. The Journal of allergy and clinical immunology 2008 Jun; 121(6).
Blázquez AB, Berin MC. Gastrointestinal dendritic cells promote Th2 skewing via OX40L. Journal of immunology (Baltimore, Md. : 1950) 2008 Apr; 180(7).
Li H, Chehade M, Liu W, Xiong H, Mayer L, Berin MC. Allergen-IgE complexes trigger CD23-dependent CCL20 release from human intestinal epithelial cells. Gastroenterology 2007 Dec; 133(6).