Margaret M McClure, PhD
- ASSISTANT PROFESSOR | Psychiatry
Dr. McClure's clinical interests include:
- Schizophrenia spectrum illnesses
- Personality Disorders
- Cognitive Remediation Therapy
- Neuropsychological Assessment
BS, Fordham University
PhD, Fordham University
Mount Sinai School of Medicine
Dr. McClure's research is aimed at understanding the scope and profile of cognitive symptoms seen in individuals with schizophrenia spectrum disorders, such as schizophrenia and schizotypal personality disorder (SPD), as well as potential mechanisms for treating these symptoms. The primary focus of her research is to evaluate cognitive remediation therapy and social skills training for individuals with schizophrenia and to examine the differential impact of these treatments on cognitive functioning, as well as occupational, social, and interpersonal functioning.
Keywords: Schizophrenia; Schizophrenia spectrum illnesses; Personality Disorders; Cognition; Cognitive Remediation Therapy; Neuropsychological Assessment
- Guanfacine Enhancement of Working Memory: Prospects for Augmenting Cognitive Remediation in the Schizophrenia Spectrum
Cognitive deficits in the schizophrenia spectrum are highly debilitating and associated with significant functional impairment. Cognitive remediation therapy (CRT) has demonstrated promise in schizophrenia, and our preliminary data from a pilot study of CRT supports continued ...
McClure MM, Barch DM, Flory JD, Harvey PD, Siever LJ. Context processing in schizotypal personality disorder: Evidence of specificity of impairment to the schizophrenia spectrum. Journal of Abnormal Psychology 2008; 117: 342-354.
Leung WW, McClure MM, Barch DM, Harvey PD, Siever LJ. Catechol-O-methyltransferase Val158Met genotype in healthy and personality disordered individuals: An examination of cognitive tests hypothetically differentially sensitive to dopamine functions. Neuropsychiatric Disease & Treatment 2007; 3: 925-934.
Bowie CR, Reichenberg A, McClure MM, Harvey PD. Age-associated differences in cognitive performance in older community dwelling schizophrenia patients: Differential sensitivity of neuropsychological and information processing tests?. Schizophrenia Research 2007 Nov 27 [Epub ahead of print];.
McClure MM, Harvey PD. Critical issues in the assessment of disability in schizophrenia. Clinical Schizophrenia & Related Psychoses 2007; 1: 147-153.
Bowie CR, Leung WW, Reichenberg A, McClure MM, Patterson TL, Heaton RK, Harvey PD. Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures. Biological Psychiatry 2007 Jul 25 [Epub ahead of print];.
McClure MM, Barch DM, Romero MJ, Minzenberg MJ, Treibwasser J, Harvey P, Siever LJ. The effects of guanfacine on context processing abnormalities in schizotypal personality disorder. Biological Psychiatry 2007; 20: 1157-1160.
McClure MM, Romero MJ, Bowie CR, Reichenberg A, Harvey PD, Siever LJ. Visual-spatial learning and memory in schizotypal personality disorder: Continued evidence for the importance of working memory in the schizophrenia spectrum. Archives of Clinical Neuropsychology 2007; 22: 109-116.
McClure MM, Bowie CR, Patterson TL, Heaton RK, Weaver C, Anderson H, Harvey PD. Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: Evidence of specificity of relationships? . Schizophrenia Research 2007; 89: 330-338.
McClure MM, Zegarelli G, Bowie CR, Mitropoulou V, Siever LJ, Harvey PD. Cognitive impairment in the schizophrenia spectrum: What is the evidence for similarity to schizophrenia? . Current Psychosis & Therapeutics Reports 2006; 4: 128-133.
Harvey PD, McClure MM. Pharmacological approaches to the management of cognitive dysfunction in schizophrenia. Drugs 2006; 66: 1465-1473.