Maria Soledad Sosa

Maria Soledad Sosa, PhD

  • ASSISTANT PROFESSOR | Medicine, Hematology and Medical Oncology

My undergraduate training consisted in the study of melanoma biology, in the laboratory of Osvaldo Podhajcer at the renowned Leloir Institute where I focused in the identification of novel melanoma signaling targets using proteomics. From this training phase I published a very complete story in Proteomics (Sosa MS, et al., Proteomics 2007). My Ph.D. training program was carried out at the University of Pennsylvania in a joint program with the University of Buenos Aires. This training was under the mentorship of Dr. Marcelo Kazanietz, a well-recognized scientist in cell signaling studies in prostate and breast cancer. During this time I focused on the study of P-Rex1, a Rac-GEF protein, and how this factor contributes to the malignancy of mammary tumor cells. We demonstrated that P-Rex1 is important for migration and tumor development of breast cancer cells (Sosa MS, et al., Mol. Cell 2010). In 2010, I joined Dr. Julio Aguirre-Ghiso laboratory and since then I have been working in understand how tumor cell dormancy is established once tumor cell disseminate to secondary organs. In this work I was able to link the orphan nuclear receptor NR2F1 to a novel function during tumor cell dormancy (Sosa Nat. Com 2015). I found that NR2F1 is required for malignant cells to undergo dormancy and it does this by upregulating the expression of cell cycle inhibitors and decreasing cyclin D1 levels. I also found that NR2F1 induces the mRNA levels of NANOG, SOX2 and OCT-4 in dormant cells. The latter result is surprising and important since it is the first time that a connection between self-renewal genes and quiescence programs has been established in tumor cells and dormancy. In 2012 I was awarded a DoD Breast Cancer Postdoctoral Grant to study the processes responsible for dissemination and target organ colonization by breast tumor cells. In 2015 I was promoted to Assistant Professor position in the Department of Medicine, Icahn School of medicine at Mount Sinai.

Multi-Disciplinary Training Areas

Biophysics and Systems Pharmacology [BSP], Cancer Biology [CAB]


PhD, University of Buenos Aires/University of Pennsylvania