Meerarani Purushothaman, PhD
- ASSISTANT PROFESSOR | Medicine, Cardiology
Dr. Meerarani received her doctorate degree in biochemistry at the University of Madras in India. Her research work with Dr. B.Hennig at the Molecular and Cell Nutrition Laboratory, University of Kentucky has focused on the role of nutrients on biochemical and molecular mechanism of vascular endothelial cell function, injury and protection during the development of atherosclerotic disease process.
Dr. Meerarani's research at Mount Sinai is focused along with Dr. Juan Badimon and Dr. Pedro Moreno, in studying the macrophage apoptosis and thrombogenicity, with emphasis in the involvement of tissue factor and tissue factor pathway inhibitor in the development of atherothrombosis. More specifically, using in vivo and in vitro (macrophage and endothelial) cell culture models, the activation of intrinsic and extrinsic coagulation pathways linking cardiovascular risk factors (inflammation, diabetes, hyperlipidemia and smoking) in inducing cell death and thrombogenicity are being studied. Immunofluorescence labeling, flow cytometry, gene and protein expression studies and specific ELISA techniques are being used to investigate the mechanisms involved in linking specific apoptotic pathways with thrombogenicity and tissue factor expression and activity. In addition, she is involved in studying the molecular mechanism of endothelial dysfunction of neovessels in plaque progression and rupture in atherosclerosis.
Hennig B, Purushothaman M, Slim R, Toborek M, Daugherty A, Silverstone AE, Robertson LW. Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 2002; 181: 174-183.
Purushothaman M, Smart EJ, Toborek M, Boissonneault GA, Hennig B. Cholesterol attenuates linoleic acid-induced endothelial cell activation. Metabolism 2003; 52: 493-500.
Purushothaman M, Reiterer G, Toborek M, Hennig B. Zinc Modulates PPAR Signaling and Activation of Porcine Endothelial Cells. J Nutr 2003; 133: 3058-3064.