Depression Research

Major Depressive Disorder

Major depressive disorder is a serious medical condition that affects approximately 14 million Americans every year. Major depressive disorder is characterized by feeling down or hopeless for weeks at a time and is different from a passing sad or blue mood.

Depression can affect every part of a person's life, including their ability to work, sleep, eat, and enjoy people and activities. Some people experience a few symptoms while others may experience a variety. Severity of symptoms also varies with individuals.

While people with depression often feel that nothing can help them, there are several effective treatments for depression. The first step to getting appropriate treatment for depression is a physical examination by a physician. Once diagnosed, treatment for depression includes psychotherapy, light therapy, and medication, or a combination of these treatments. In the most severe cases, electroconvulsive therapy (ECT) and vagus nerve stimulation (VNS) are therapeutic options.

Visit our Health Library for more information about major depressive disorder.

Clinical Trials for Depression Disorders

Experts at the Mood and Anxiety Disorders Program at the Mount Sinai School of medicine are conducting studies of investigational medications that may help relieve your depression symptoms. We are seeking individuals who are interested in participating in the following clinical trials.

Optimization of IV Ketamine in Treatment-Resistant Major Depression

A Double-Blind, Paroxetine- and Placebo-Controlled Study of 50 mg/day and 100 mg/day of EB-1010 among Outpatients with Major Depressive Disorder Who have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

Evaluation of Low Emission Neosync EEG Synchronized TMS Technology for the Treatment of Major Depressive Disorder: A Multicenter Randomized, Double-Blind, Sham-Controlled Trial

Cognitive Training for Depression

Continuation Intravenous Ketamine Major Depressive Disorder

An fMRI Study of Ketamine in Treatment-Resistant Depression

To participate in one of our clinical trials for Mood and Anxiety Disorders or to learn more about eligibility, please contact us at 212-241-0961 or e-mail us at MAP@mssm.edu.