Shared Research Facilities (SRF)
In-Vivo Molecular Imaging Shared Facility
Icahn Medical Institute, Animal Facility
One Gustave L. Levy Place, Box 1234
New York, NY 10029
Tel: (212) 241-7255
Fax: (212) 534-2683
 The IMIL (In-vivo Molecular Imaging Laboratory) offers in-vivo biophotonic imaging services which allow researchers to use real-time imaging to monitor and record cellular and genetic activities within a living organism. One of the key components for optical imaging is the enzyme luciferase. Luciferase can be incorporated in the genes of  other cells and when activated it emits light which can be used for imaging purposes. By injecting these tagged cells into an animal and monitor the light emitted, researchers can track the spread of disease and effects of treatments. Transgenic animals where the luciferase gene is under control of specific promoters are also available. The ability to monitor disease processes in-vivo at multiple time-points allow more accurate scientific experiments as well as more efficient use of animals in research. Although the IVIS-200 is designed for in-vivo imaging application, it can also be used for in-vitro experiments with cell cultures.
 The laboratory is equipped with the top of the line Xenogen IVIS-200 imaging system with the fluorescence XFO-12 option. The system can image 5 mice simultaneously under isoflurane anesthesia. A set of spectral filters covering wavelengths from 420nm to 740nm allows for more precise localization of the target source. The fluorescent option provides for a wide range of excitation and detection wavelengths. The system is located in the Mt. Sinai animal facility behind the barrier as most users house their animals there. The IVIS-200 imaging system is equipped with a workstation for post-processing and quantitative analysis. The system is networked to the hospital backbone and data can be electronically transferred to the researcher’s laboratory. We have a dedicated animal technologist who will perform all the imaging procedures and post processing of data. The facility provides technical assistance as well as consultation for investigators interested in using the facility.
Web Site www.mssm.edu/research/resources/molecular_imaging/
Contact Person
Cheuk Ying Tang, Ph.D., Director In-Vivo Molecular Imaging Shared Facility
Tel: (212) 241-7255
E-mail: cheuk.tang@mssm.edu
Contact Cheuk Tang for questions concerning the planning of experiments, advice on image analysis and special applications.
For Scheduling
Yu Zhou, M.S.
Tel: (212) 659-1590
E-mail: yu.zhou@mssm.edu
Contact the Animal Technician for reservations and assistance with experiments.
For Billing Issues
Andrea King-Vilaro
E-mail: andrea.king@mssm.edu
Consultation Times
By appointment only, please contact cheuk.tang@mssm.edu
Custom Services
Specialized image analysis, e.g., coregistration of IMIL data with structural
MRI or other modalities. Please contact the Director.
Prices for services are available to computers on Mount Sinai networks only. For information about fees, please contact the Shared Research Facility.
Seminar Schedule
None Scheduled
Shared Research Facilities
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