Tumor Cytogenetics Departmental Core

Tumor Cytogenetics Laboratory

Departmental Core, the Tumor Cytogenetics Laboratory provides conventional and molecular cytogenetics services for patients with leukemia, lymphoma, and other related diseases, as well as for patients with solid tumors, such as breast cancers, in which chromosomal and molecular abnormalities have diagnostic and/or prognostic significance.

Conventional cytogenetics and different FISH (Fluorescence In Situ Hybridization) methods are complementary techniques used to investigate the genome rearrangements of malignant cells. Conventional cytogenetics is the comprehensive study of all chromosomes. FISH study is a more sensitive technology that allows detection of the number, size, and location of DNA and RNA segments within individual cells either in tissue sections or in whole cell populations.

The Tumor Cytogenetics Laboratory offers clinical cytogenetic and FISH tests for:

• Numerical and structural chromosome abnormalities
• Disease-specific gene rearrangements
• Disease-specific locus deletion
• Amplification of loci
• Monitoring engraftment, chimerisam, and minimal residual disease after hematopoietic stem cell transplantation.

The research aspect of the laboratory includes delienation of genetic events involved in multistep pathogenesis of myeloid disorders.

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