At the Mount Sinai Children’s Brain and Spinal Tumor Center we publish a variety of research pertaining to the understanding of the molecular underpinnings of several types of pediatric brain tumors.
DIPG/DMG & Pediatric High-Grade Glioma
Tomita Y, Shimazu Y, Somasundaram A, Tanaka Y, Takata N, Ishi Y, Gadd S, Hashizume R, Angione A, Pinero G, Hambardzumyan D, Brat DJ, Hoeman CM, Becher OJ. A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell-of-origin dependent effects of H3K27M. Glia 2022; Online ahead of print
Dhar S, Gadd S, Patel P, Vaynshteyn J, Raju GP, Hashizume R, Brat DJ, Becher OJ. A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis. Acta Neuropathol Commun 2022; 10(1):47
Ross JL, Velazquez Vega J, Plant A, MacDonald TJ, Becher OJ, Hambardzumyan D. Tumor immune landscape of paediatric high-grade gliomas. Brain 2021; 144(9):2594-2609.
Ross JL, Chen Z, Herting CJ, Grabovska Y, Szulzewsky F, Puigdelloses M, Monterroza L, Switchenko J, Wadhwani NR, Cimino PJ, Mackay A, Jones C, Read RD, MacDonald TJ, Schniederjan M, Becher OJ, Hambardzumyan D. Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma. Brain 2021; 144(1):53-69.
Hoeman CM, Cordero FJ, Hu G, Misuraca K, Romero MM, Cardona HJ, Nazarian J, Hashizume R, McLendon R, Yu P, Procissi D, Gadd S, Becher OJ. ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma. Nat Commun 2019; 10(1):1023.
Medulloblastoma
Tylawsky DE. Kiguchi H, Vaynshteyn J, Gerwin J, Shah J, Islam T, Boue DR, Snuderl M, Greenblatt MB, Shamay Y, Raju GP, Heller DA. P-selectin stimulates caveolin-1 mediated endothelial transcytosis in medulloblastoma. 2021; preprint DOI:10.21203/rs.3.rs-658944/v1
Maximov V, Chen Z, Wei Y, Robinson MH, Herting CJ, Shanmugam NS, Rudneva VA, Goldsmith KC, MacDonald TJ, Northcott PA, Hambardzumyan D, Kenney AM. Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma. Nat Commun 2019; 10(1):2410.
Neuroimmunology
Chen Z, Herting CJ, Ross JL, …, Read RD, Hambardzumyan D. Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. Glia 2020; 68(10):2148-2166.
Herting CJ, Chen Z, Maximov V, Duffy A, Szulzewsky F, Shayakhmetov DM, Hambardzumyan D. Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma associated cerebral oedema. Brain 2019; 142(12):3834-3851.
Cancer Proteogenomics
Petralia F, Tignor N,…Resnick A, Storm PB, Rood BR, Wang P; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium. Integrated proteogenomic characterization across major histological types of pediatric brain cancer. Cell 2020; 183(7):1962-1985.
Wang LB, Karpova A,…Resnick A, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L; Clinical Proteomic Tumor Analysis Consortium. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell 2021; 39(4):509-528.
Cancer Epigenomics
Lewis PW, Muller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 2013; 340(6134):857-61.
Qadeer ZA, Valle-Garcia D, …, Maris JM, Weiss WA, Roberts SS, Cheung NV, Jin J, Segura MF, Dyer MA, Bernstein E. ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures. Cancer Cell 2019; 36(5):512-527.
Tome-Garcia J, Erfani P, Nudelman G, Tsankov A, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Analysis of chromatin assembly uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun 2018; 9(1):4020.
Cancer Metabolism
Marin-Valencia I, …Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab 2012; 15(6):827-37.
Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA. Measurement of 13C turnover into glutamate and glutamine pools in brain tumor patients. FEBS Lett 2017; 591(21):3548-3554.