Resource Core B “Modeling of Skin Disease for Mechanistic Analysis and Therapeutic Discovery” helps to perform cutting edge imaging methods; assists with isolation of skin cell subpopulations for analysis; consults and aids in the generation and analysis of genetically altered mice for mechanistic studies and disease modeling; and provides sophisticated CRISPR technologies for gene editing and gene expression manipulation screens in human iPSC-derived skin cells to model disease, explore mechanisms, and establish therapeutic screening platforms. Learn more.

Resource Core C “Skin Genomics, Transcriptomics, and Epigenetics Core” provides access to methods for genomics (exome sequencing, whole genome sequencing, and targeted capture), transcriptomics (RNA-seq, ISO-seq, small RNA seq), epigenetic (ATAC-seq, ChIP-seq, CUT&RUN, Hi-C), and single-cell (scRNA-seq, scATAC-seq, spatial transcriptomics) analysis of normal and diseased skin. Learn more.

Resource Core D “Data Analysis and Integration Core” provides a reduced cost, start-to-finish standardization of bioinformatic and statistical services for Cores B and C and integrates generated datasets to provide information in a manner that is easily accessible to the research community. Core D will also release Skin-GLOW (Skin-Gene Level Omic Web Tool), an online tool to allow an interactive gene- and sample-centric visualization of multi-omic datasets from multiple platforms (RNA-seq, ATAC-seq, ChIP-seq, HiC, scRNA-seq and scATAC-seq). Learn more.