Core C provides state-of-the-art start-to-finish technologies for genomics, transcriptomics, epigenetic, and single-cell analysis of the skin in homeostasis and disease.
Core C Leadership
Director: Anne Bowcock, PhD, Professor of Dermatology, Oncological Sciences, and Genetics and Genomic Sciences
Co-Director: Robert Sebra, PhD, Associate Professor of Genetics and Genomic Sciences and Director of The Center for Advanced Genomics Technology.
Core C Services
Core C facilitates access to:
- Genomics technologies such as exome sequencing, whole-genome sequencing, and targeted capture
- Transcriptomic methods (bulk ribonucleic acid (RNA)-seq, poly(A) RNA-seq, and small RNA-seq)
- Long-read single-molecule sequencing (SMRT/PacBio) to facilitate analysis of structural changes in DNA and the precise identification of RNA isoforms due to altered splicing
- Epigenetic technologies such as assay for transposase-accessible chromatin (ATAC) with high-throughput sequencing, chromatin immunoprecipitation (ChIP) -seq, and CUT&RUN) to identify DNA regulatory elements
- Single-cell (sc) technologies for transcript (scRNA-seq), epigenetic (scATAC-seq), and multiomics (scGEX+ATAC) analyses
- CITE-Seq technology for simultaneous epitope and transcriptome measurements of single cells
- Spatial transcriptomics analyses
Upon user request, data obtained by Core C will be supplied to SBDRC Resource Core D Data Analysis and Integration, where computational biologists will perform rigorous analysis, visualization, and data management.
To learn more about these services, please contact Dr. Bowcock and Dr. Sebra or visit our website.